ArticleEJNMMI research2011
Quantitative assessment of brown adipose tissue metabolic activity and volume using 18F-FDG PET/CT and β3-adrenergic receptor activation.
Article in EJNMMI research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 76 citations in OpenAlex.
- Acute effect of propranolol on resting energy expenditure in hyperthyroid patients.Frontiers in endocrinology · 2022Trial
- Imaging [bioRxiv : the preprint server for biology · 2026Article
- Distribution patterns of brown adipose tissue on FDG-PET/CT has age characteristics.Annals of nuclear medicine · 2025Article
- Irisin reverses high-fat diet-induced metabolic dysfunction via activation of brown adipose tissue in mice.International journal of obesity (2005) · 2025Article
- Role of Brown Adipose Tissue in Metabolic Health and Efficacy of Drug Treatment for Obesity.Journal of clinical medicine · 2024Article
- Advances in Preclinical PET.Seminars in nuclear medicine · 2022Review
- Article
- Lean in one way, in obesity another: effects of moderate exercise in brown adipose tissue of early overfed male Wistar rats.International journal of obesity (2005) · 2022Article
- The Effect of Hyperbaric Therapy on Brown Adipose Tissue in Rats.International journal of environmental research and public health · 2021Article
- A Differential Pattern of Batokine Expression in Perivascular Adipose Tissue Depots From Mice.Frontiers in physiology · 2021Article
- Leucine Potentiates Glucose-mediatedBiomedicines · 2020Article
- Effects of resveratrol and its derivative pterostilbene on brown adipose tissue thermogenic activation and on white adipose tissue browning process.Journal of physiology and biochemistry · 2020Review
- The Role of Leptin Levels in Adaptation to Cold Climates.International journal of environmental research and public health · 2020Article
- Neurocognitive Disorders in Heart Failure: Novel Pathophysiological Mechanisms Underpinning Memory Loss and Learning Impairment.Molecular neurobiology · 2019Review
- PET imaging study of brown adipose tissue (BAT) activity in mice devoid of receptor for advanced glycation end products (RAGE).Journal of biosciences · 2019Article
- Characterization of Brown Adipose Tissue in a Diabetic Mouse Model with Spiral Volumetric Optoacoustic Tomography.Molecular imaging and biology · 2019Article
- Article
- Evaluation of Glucose Uptake and Uncoupling Protein 1 Activity in Adipose Tissue of Diabetic Mice upon β-Adrenergic Stimulation.Molecular imaging and biology · 2019Article
- Adult Hippocampal Neurogenesis Can Be Enhanced by Cold Challenge Independently From Beigeing Effects.Frontiers in neuroscience · 2019Article
- Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundBrown adipose tissue [BAT] metabolism in vivo is vital for the development of novel strategies in combating obesity and diabetes. Currently, BAT is activated at low temperatures and measured using 2-deoxy-2-18F-fluoro-D-glucose [18F-FDG] positron-emission tomography [PET]. We report the use of β3-adrenergic receptor-mediated activation of BAT at ambient temperatures using (R, R)-5-[2-[2,3-(3-chlorphenyl)-2-hydroxyethyl-amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate, disodium salt [CL316,243] (a selective β3-adrenoceptor agonist) and measured by 18F-FDG PET/computed tomography [CT].
methodsControl and CL316,243-treated (2 mg/kg) male Sprague-Dawley rats were administered with 18F-FDG for PET/CT studies and were compared to animals at cold temperatures. Receptor-blocking experiments were carried out using propranolol (5 mg/kg). Dose effects of CL316,243 were studied by injecting 0.1 to 1 mg/kg 30 min prior to 18F-FDG administration. Imaging results were confirmed by autoradiography, and histology was done to confirm BAT activation.
resultsCL316,243-activated interscapular BAT [IBAT], cervical, periaortic, and intercostal BATs were clearly visualized by PET. 18F-FDG uptake of IBAT was increased 12-fold by CL316,243 vs. 1.1-fold by cold exposure when compared to controls. 18F-FDG uptake of the CL-activated IBAT was reduced by 96.0% using intraperitoneal administration of propranolol. Average 18F-FDG uptake of IBAT increased 3.6-, 3.5-, and 7.6-fold by doses of 0.1, 0.5, and 1 mg/kg CL, respectively. Ex vivo 18F-FDG autoradiography and histology of transverse sections of IBAT confirmed intense uptake in the CL-activated group and activated IBAT visualized by PET.
conclusionOur study indicated that BAT metabolic activity could be evaluated by 18F-FDG PET using CL316,243 at ambient temperature in the rodent model. This provides a feasible and reliable method to study BAT metabolism.
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Registered trials
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