Evidence map›Paper›PMID 22213602›Full record

ArticleArchives of pediatrics & adolescent medicine2012

Exposure to gestational diabetes mellitus and low socioeconomic status: effects on neurocognitive development and risk of attention-deficit/hyperactivity disorder in offspring.

Yoko Nomura, David J Marks, Bella Grossman, Michelle Yoon, Holly Loudon, Joanne Stone, Jeffrey M Halperin

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of pediatrics & adolescent medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 9 pooled it
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 9 syntheses or guidelines pooled it, 198 citations in OpenAlex.

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41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yoko NomuraDepartment of Psychology, Queens College, City University of New York, 65-30 Kissena Blvd, Flushing, NY 11376, USA. Yoko.Nomura@qc.cuny.edu
David J Marks
Bella Grossman
Michelle Yoon
Holly Loudon
Joanne Stone
Jeffrey M Halperin
Icahn School of Medicine at Mount Sinai · US

Funding

Predictors of Attention Deficit Hyperactivity Disorder in Preschool ChildrenR01MH068286 · NIMH · QUEENS COLLEGE · PI HALPERIN, JEFFREY M · 2004 to 2013
$5.8M
Perinatal risk factors and genetic susceptibility for childhood psychopathologyK01MH080062 · NIMH · QUEENS COLLEGE · PI NOMURA, YOKO · 2008 to 2012
$987k
VALISATION OF INANTTENTIVE &AGGRESSIVE ADHD SUBTYPESR01MH046448 · NIMH · QUEENS COLLEGE · PI HALPERIN, JEFFREY M · 1990 to 1997
–
NIMH NIH HHS K01 MH080062NIMH NIH HHS K01MH080062NIMH NIH HHS R01 MH046448NIMH NIH HHS R01MH046448NIMH NIH HHS R01 MH068286
6 · The paper itself

Abstract

objectiveTo examine the independent and synergistic effects of gestational diabetes mellitus (GDM) and low socioeconomic status (SES) on neurodevelopment and attention-deficit/hyperactivity disorder (ADHD) outcomes.

designCohort study.

settingFlushing, New York.

participantsA total of 212 preschool children as a part of the ongoing cohort study. MAIN EXPOSURES: Gestational diabetes mellitus and low SES.

main outcome measuresPrimary outcomes are ADHD diagnosis based on Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) criteria at age 6 years and several well-validated measures of neurobehavioral outcomes, cognitive functioning, ADHD symptoms, and temperament at age 4 years. Secondary outcomes are parent and teacher reports of behavioral and emotional problems at age 6 years. Neurobehavioral measures in relation to GDM and low SES were examined using generalized estimating equations and multivariate logistic regression analyses.

resultsBoth maternal GDM and low SES were associated with an approximately 2-fold increased risk for ADHD at age 6 years. However, the risk by GDM was greater among lower SES families than among higher SES families. Children exposed to both GDM and low SES demonstrated compromised neurobehavioral functioning, including lower IQ, poorer language, and impoverished behavioral and emotional functioning. A test of additive interaction found that the risk for ADHD increased over 14-fold (P = .006) when children were exposed to both GDM and low SES. Neither children exposed to maternal GDM alone nor those exposed to low SES alone had a notable increased risk for ADHD.

conclusionsMaternal GDM and low SES, especially in combination, heighten the risk for childhood ADHD. Long-term prevention efforts should be directed at mothers with GDM to avoid suboptimal neurobehavioral development and mitigate the risk for ADHD among their offspring.

Indexed as

Child DevelopmentPovertyAdultAttention Deficit Disorder with HyperactivityChild, PreschoolCognitionDiabetes, GestationalFemaleFollow-Up StudiesHumansMaleNew YorkParentsPregnancyPrevalenceRisk Factors

Identifiers

PMID22213602
PMCPMC5959273
OpenAlexW2108393255

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.