Evidence map›Paper›PMID 22213511›Full record

ReviewJournal of cellular biochemistry2012

Non-coding RNAs as theranostics in human cancers.

Roxana S Redis, Ioana Berindan-Neagoe, Victor I Pop, George A Calin

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cellular biochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Observational
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  10. Nanoscale delivery systems for microRNAs in cancer therapy.Cellular and molecular life sciences : CMLS · 2020
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4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

4 authors.

Roxana S RedisDepartment of Molecular Science, University of Medicine and Pharmacy I. Hatieganu, Cluj-Napoca, Romania.
Ioana Berindan-Neagoe
Victor I Pop
George A Calin

Funding

Center for Clinical and Translational Sciences (CCTS)KL2TR000370 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$4.3M
MicroRNAs and other non-coding RNAs in Colorectal MetastasisR01CA135444 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CALIN, GEORGE A., DAVULURI, RAMANA V · 2009 to 2010
$651k
NCATS NIH HHS KL2 TR000370NCI NIH HHS CA135444NCI NIH HHS R01 CA135444
6 · The paper itself

Abstract

Theranostics was coined originally as a term used to describe a system that combines diagnosis and therapy, aiming to provide the tools for personalized medicine. This review reasserts the grounds for regarding non-coding RNAs (ncRNA) as theranostics in human cancers. The microRNAs (miRNAs) are the most well studied ncRNAs in recent years; their pivotal role in orchestrating tumor initiation and progression has been confirmed in all types of cancers. Hence, these small ncRNAs have emerged as attractive therapeutic targets and diagnostic tool. Various approaches to use their therapeutic potential have been taken, here we summarize the most important ones. In the near future, the focus of theranostics will be shifted towards longer and mechanistically more versatile ncRNAs, and we included some recent advances supporting this view.

Indexed as

DependovirusDrug Resistance, NeoplasmGenes, Tumor SuppressorGenetic VectorsHumansMicroRNAsMolecular MimicryNanoparticlesNeoplasmsOligonucleotidesOncogenesPrecision MedicineRNA, AntisenseRNA, NeoplasmRNA, Untranslatedlocked nucleic acidMicroRNAsOligonucleotidesRNA, AntisenseRNA, NeoplasmRNA, Untranslated

Identifiers

PMID22213511
PMCPMC3337365

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.