ArticleMagnetic resonance in medicine2012
Magnetization transfer MRI in pancreatic cancer xenograft models.
Article in Magnetic resonance in medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- Co-Clinical Evaluation of Synthetic Vitamin D and Chemotherapy in Pancreatic Cancer by Integrated Imaging and Molecular Analyses.Cancer research communications · 2026Trial
- Deep learning reconstruction-applied PROPELLER diffusion-weighted imaging in uterine malignancies: a comparison study with MUSE.Japanese journal of radiology · 2026Article
- Investigating the contribution of hyaluronan to the breast tumour microenvironment using multiparametric MRI and MR elastography.Molecular oncology · 2023Article
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- Bimodal magnetic resonance and optical imaging of extracellular matrix remodelling by orthotopic ovarian tumours.British journal of cancer · 2020Article
- Water and Collagen Content Are High in Pancreatic Cancer: Implications for Quantitative Metabolic Imaging.Frontiers in oncology · 2020Article
- Translating preclinical MRI methods to clinical oncology.Journal of magnetic resonance imaging : JMRI · 2019Review
- Evaluation of pancreatic tumor development in KPC mice using multi-parametric MRI.Cancer imaging : the official publication of the International Cancer Imaging Society · 2018Article
- Characterisation of fibrosis in chemically-induced rat mammary carcinomas using multi-modal endogenous contrast MRI on a 1.5T clinical platform.European radiology · 2018Article
- Magnetisation transfer as a biomarker for chronic airway fibrosis in a mouse lung transplantation model.European radiology experimental · 2018Article
- Non-invasive tracking of disease progression in young dystrophic muscles using multi-parametric MRI at 14T.PloS one · 2018Article
- Molecular MR imaging of fibrosis in a mouse model of pancreatic cancer.Scientific reports · 2017Article
- Chemical Shift magnetization transfer magnetic resonance imaging.Magnetic resonance in medicine · 2017Article
- Noninvasive characterization of pancreatic tumor mouse models using magnetic resonance imaging.Cancer medicine · 2017Article
- Improved Treatment of Pancreatic Cancer With Drug Delivery Nanoparticles Loaded With a Novel AKT/PDK1 Inhibitor.Pancreas · 2016Article
- Influence of water compartmentation and heterogeneous relaxation on quantitative magnetization transfer imaging in rodent brain tumors.Magnetic resonance in medicine · 2016Article
- Magnetization transfer imaging of normal and abnormal testis: preliminary results.European radiology · 2016Article
- Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer.Gastroenterology · 2015Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Magnetization transfer magnetic resonance imaging measurements were performed in three pancreatic ductal adenocarcinoma mouse xenograft models. For each of 28 pancreatic ductal adenocarcinoma xenografts, MT ratios (MTRs) were calculated and compared to histologic fibrosis levels from reference standard trichrome staining. MTR was found to be significantly higher in tumors grown using BxPC-3 cell line (39.4±5.1, mean±SD) compared to the MTR for the tumors grown from Panc-1 (32.4±2.8) and Capan-1 (27.3±2.9) cell lines (P<0.05 for each comparison). Histologic measurements showed a similar trend with BxPC-3 tumors demonstrating significantly higher fibrosis levels (percentage of fibrotic tissue area, 6.48±2.59) when compared to Panc-1 (3.54±2.18) and Capan-1 (2.07±1.60) tumors. MTR measurements were well correlated to quantitative fibrosis levels (r=0.69, P=0.01). Results indicated that MTR measurements offer the potential to serve as a valuable in vivo biomarker of desmoplasia in pancreatic ductal adenocarcinoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.