Evidence map›Paper›PMID 22213121›Full record

ReviewJournal of cellular biochemistry2012

Medical therapies with adult stem/progenitor cells (MSCs): a backward journey from dramatic results in vivo to the cellular and molecular explanations.

Darwin J Prockop, Joo Youn Oh

Abstract readReview
In one paragraph

Review in Journal of cellular biochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Intrathecal Administration of an Anti-nociceptive Non-CpG Oligodeoxynucleotide Reduces Glial Activation and Central Sensitization.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021
    Article
  9. Review
  10. Review
  11. IMT504 Provides Analgesia by Modulating Cell Infiltrate and Inflammatory Milieu in a Chronic Pain Model.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021
    Article
  12. AnPathology oncology research : POR · 2021
    Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Darwin J ProckopInstitute for Regenerative Medicine, Texas A&M Health Science Center College of Medicine at Scott & White, Temple, Texas 76502, USA. Prockop@medicine.tamhsc.edu
Joo Youn Oh

Funding

Marrow Stromal Cell Homing to the Lung in EmphysemaP01HL075161 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI PHINNEY, DONALD G · 2005 to 2009
$9.1M
PREPARATION AND DISTRUBUTION OF ADULT STEM CELLS: HUMAN &RODENTP40RR017447 · NCRR · TULANE UNIVERSITY OF LOUISIANA · PI PROCKOP, DARWIN JOHNSON · 2003 to 2011
$8.9M
Adult Stem Cells for Repair of Cardiac DamageR01HL073755 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI PROCKOP, DARWIN JOHNSON · 2003 to 2010
$3.1M
Adult Stem Cells/Progenitor Cells for Treatment of Corneal Injuries and DiseasesR21EY020962 · NEI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI PROCKOP, DARWIN JOHNSON · 2010 to 2011
$396k
NCRR NIH HHS P01 RR 17447NCRR NIH HHS P40 RR017447NEI NIH HHS 1R21EY020962NEI NIH HHS R21 EY020962NHLBI NIH HHS HL 073755NHLBI NIH HHS P01 HL 075161NHLBI NIH HHS P01 HL075161NHLBI NIH HHS R01 HL073755
6 · The paper itself

Abstract

There is currently great interest in the use of mesenchymal stem/stromal cells (MSCs) for the therapy of many diseases of animals and humans. However, we are still left with the serious challenges in explaining the beneficial effects of the cells. Hence, it is essential to work backward from dramatic results obtained in vivo to the cellular and molecular explanations in order to discover the secrets of MSCs. This review will focus on recent data that have changed the paradigms for understanding the therapeutic potentials of MSCs.

Indexed as

Mesenchymal Stem Cell TransplantationAdult Stem CellsAnimalsApoptosisHumansInflammationMesenchymal Stem CellsTranslational Research, BiomedicalWound Healing

Identifiers

PMID22213121
PMCPMC4147853

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.