ArticleStem cells (Dayton, Ohio)2012
Protein kinase C mediated extraembryonic endoderm differentiation of human embryonic stem cells.
Article in Stem cells (Dayton, Ohio), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- The Role of Protein Kinase C During the Differentiation of Stem and Precursor Cells into Tissue Cells.Biomedicines · 2024Review
- A Quick and Efficient Method for the Generation of Immunomodulatory Mesenchymal Stromal Cell from Human Induced Pluripotent Stem Cell.Tissue engineering. Part A · 2022Article
- All models are wrong, but some are useful: Establishing standards for stem cell-based embryo models.Stem cell reports · 2021Review
- Mesenchymal Stem Cell-Mediated Mitochondrial Transfer: a Therapeutic Approach for Ischemic Stroke.Translational stroke research · 2021Review
- Review
- 12-O-Tetradecanoylphorbol-13-acetate increases cardiomyogenesis through PKC/ERK signaling.Scientific reports · 2020Article
- Dynamic Alternative Splicing During Mouse Preimplantation Embryo Development.Frontiers in bioengineering and biotechnology · 2020Article
- Reprogrammed Cells Display Distinct Proteomic Signatures Associated with Colony Morphology Variability.Stem cells international · 2019Article
- Functional interaction of PkcA and PldB regulate aggregation and development in Dictyostelium discoideum.Cellular signalling · 2017Article
- An atlas of human kinase regulation.Molecular systems biology · 2016Article
- New markers for tracking endoderm induction and hepatocyte differentiation from human pluripotent stem cells.Development (Cambridge, England) · 2015Article
- Absence of catalytic domain in a putative protein kinase C (PkcA) suppresses tip dominance in Dictyostelium discoideum.Developmental biology · 2015Article
- Molecular basis of embryonic stem cell self-renewal: from signaling pathways to pluripotency network.Cellular and molecular life sciences : CMLS · 2015Review
- The human embryonic stem cell proteome revealed by multidimensional fractionation followed by tandem mass spectrometry.Proteomics · 2015Article
- Protein kinase C-induced early growth response protein-1 binding to SNAIL promoter in epithelial-mesenchymal transition of human embryonic stem cells.Stem cells and development · 2014Article
- Single-cell gene expression profiles define self-renewing, pluripotent, and lineage primed states of human pluripotent stem cells.Stem cell reports · 2014Article
- A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog.Development (Cambridge, England) · 2014Article
- Protein kinases and associated pathways in pluripotent state and lineage differentiation.Current stem cell research & therapy · 2014Review
- Article
- Signaling networks in human pluripotent stem cells.Current opinion in cell biology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Unlike mouse embryonic stem cells (ESCs), which are closely related to the inner cell mass, human ESCs appear to be more closely related to the later primitive ectoderm. For example, human ESCs and primitive ectoderm share a common epithelial morphology, growth factor requirements, and the potential to differentiate to all three embryonic germ layers. However, it has previously been shown that human ESCs can also differentiate to cells expressing markers of trophoblast, an extraembryonic lineage formed before the formation of primitive ectoderm. Here, we show that phorbol ester 12-O-tetradecanoylphorbol 13-acetate causes human ESCs to undergo an epithelial mesenchymal transition and to differentiate into cells expressing markers of parietal endoderm, another extraembryonic lineage. We further confirmed that this differentiation is through the activation of protein kinase C (PKC) pathway and demonstrated that a particular PKC subtype, PKC-δ, is most responsible for this transition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.