ArticleThe pharmacogenomics journal2013
A polymorphism in the thyroid hormone receptor gene is associated with bronchodilator response in asthmatics.
Article in The pharmacogenomics journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Genome-wide association study in minority children with asthma implicates DNAH5 in bronchodilator responsiveness.Scientific reports · 2022Pooled it
- A genome-wide analysis of the response to inhaled β2-agonists in chronic obstructive pulmonary disease.The pharmacogenomics journal · 2016Pooled it
- Diagnostic accuracy of the bronchodilator response in children.The Journal of allergy and clinical immunology · 2013Trial
- Thyroid Hormone Pathways in Respiratory Diseases: Mechanism and Therapeutic Potential.Journal of inflammation research · 2025Article
- Evaluation of Polygenic Risk Score for Prediction of Childhood Onset and Severity of Asthma.International journal of molecular sciences · 2024Article
- Review
- Review
- Article
- Impact of thyroid hormones on asthma in older adults.The Journal of international medical research · 2019Article
- Pharmacogenetic Factors Affecting Asthma Treatment Response. Potential Implications for Drug Therapy.Frontiers in pharmacology · 2019Review
- Asthma Pharmacogenomics: 2015 Update.Current allergy and asthma reports · 2015Review
- Genome-wide association study of short-acting β2-agonists. A novel genome-wide significant locus on chromosome 2 near ASB3.American journal of respiratory and critical care medicine · 2015Article
- Asthma pharmacogenetics and the development of genetic profiles for personalized medicine.Pharmacogenomics and personalized medicine · 2015Review
- A genome-wide association study of bronchodilator response in Latinos implicates rare variants.The Journal of allergy and clinical immunology · 2014Article
- Airway smooth muscle in the pathophysiology and treatment of asthma.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Review
- Integrative systems biology approaches in asthma pharmacogenomics.Pharmacogenomics · 2012Review
- Genetic features of thyroid hormone receptors.Journal of genetics · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 7 institutions in 1 country.
Funding
Abstract
A pro-asthmatic culture milieu and β2-agonist (isoproterenol) were previously shown to regulate the expression of select transcription factors (TFs) within human airway epithelial and smooth muscle cells. This study tests 1116 single-nucleotide polymorphisms (SNPs) across 98 of these TF genes for association with bronchodilator response (BDR) in asthma patients. Genotyping was conducted using the Illumina HumanHap550v3 Beadchip in 403 non-Hispanic White asthmatic children and their parents. SNPs were evaluated for association with BDR using family and population-based analyses. Forty-two SNPs providing P-values <0.1 in both analyses were then genotyped in three adult asthma trials. One SNP 5' of the thyroid hormone receptor-β gene was associated with BDR in the childhood population and two adult populations (P-value=0.0012). This investigation identified a novel locus for inter-individual variability in BDR and represents a translation of a cellular drug-response study to potential personalization of clinical asthma management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.