ArticleInternational urogynecology journal2012
Local reaction to the different meshes at the vesicovaginal space in rabbit model.
Article in International urogynecology journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Managing female pelvic floor disorders: a medical device review and appraisal.Interface focus · 2019Review
- Structural differences and architectural features of two different polypropylene slings (TVT-O and I-STOP) have no impact on biocompatibility and tissue reactions.Central European journal of urology · 2017Article
- Holmium laser excision for urinary mesh erosion: a minimally invasive treatment with favorable long-term results.International urogynecology journal · 2015Article
- Animal models of female pelvic organ prolapse: lessons learned.Expert review of obstetrics & gynecology · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introduction and hypothesisThis paper aims to study the vesicovaginal space local tissue reaction to type I and II polypropylene mesh in a rabbit model.
methodsDifferent types of meshes were implanted into the rabbit vesicovaginal space. The animals were killed at days 7 and 60, and the initial implant and the neighboring host tissue were removed, including the bladder and vaginal wall. Histopathology and immunohistochemistry (Ki-67 and proliferating cell nuclear antigen) were performed to evaluate the cell proliferation, and the indirect local inflammatory response was described.
resultsOne rabbit had erosion at the urinary bladder mucous membrane, which resulted in vesical stone formation in the type I mesh group at day 60. Obvious local tissue reaction was found after the different types of meshes were implanted, and the reaction tapered and disappeared over time. At day 7, the reaction in the type I mesh group was stronger than that in the type II group, while at day 60, the reaction shows no difference.
conclusionThe two types of meshes could induce local tissue reaction, but this was stronger in type I mesh group at day 7 and shows no obvious difference between the two groups at day 60.
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Registered trials
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