ArticleCellular immunology2012
Type I interferon signaling regulates the composition of inflammatory infiltrates upon infection with Listeria monocytogenes.
Article in Cellular immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 40 citations in OpenAlex.
- Type I interferons in bacterial diseases: myeloid cells at the crossroads of protection and pathology.Frontiers in immunology · 2025Review
- Inhibition of neutrophil swarming by type I interferon promotes intracellular bacterial evasion.Nature communications · 2024Article
- Outer membrane vesicles from bacteria: Role and potential value in the pathogenesis of chronic respiratory diseases.Frontiers in cellular and infection microbiology · 2022Review
- Human Neutrophils Present Mild Activation by Zika Virus But Reduce the Infection of Susceptible Cells.Frontiers in immunology · 2022Article
- Review
- Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes.Nature communications · 2021Article
- Cutting Edge: NOX2 NADPH Oxidase Controls Infection by an Intracellular Bacterial Pathogen through Limiting the Type 1 IFN Response.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Interferons: Tug of War Between Bacteria and Their Host.Frontiers in cellular and infection microbiology · 2021Review
- Pathogenic Biohacking: Induction, Modulation and Subversion of Host Transcriptional Responses byToxins · 2020Review
- Host syndecan-1 promotes listeriosis by inhibiting intravascular neutrophil extracellular traps.PLoS pathogens · 2020Article
- Article
- Innate and Adaptive Immune Responses duringMicrobiology spectrum · 2019Article
- Crosstalk between type I and II interferons in regulation of myeloid cell responses during bacterial infection.Current opinion in immunology · 2018Review
- How does the human metapneumovirus regulate neutrophil infiltration into the airways?Future virology · 2018Article
- Human Metapneumovirus Attachment Protein Contributes to Neutrophil Recruitment into the Airways of Infected Mice.Viruses · 2017Article
- Down regulation of macrophage IFNGR1 exacerbates systemic L. monocytogenes infection.PLoS pathogens · 2017Article
- The Essential Role of Neutrophils during Infection with the Intracellular Bacterial Pathogen Listeria monocytogenes.Journal of immunology (Baltimore, Md. : 1950) · 2016Review
- IFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production.The Journal of experimental medicine · 2015Article
- CCR2 deficiency promotes exacerbated chronic erosive neutrophil-dominated chikungunya virus arthritis.Journal of virology · 2014Article
- Type I IFN suppresses Cxcr2 driven neutrophil recruitment into the sensory ganglia during viral infection.The Journal of experimental medicine · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Type I IFN is key to the immune response to viral pathogens, however its role in bacterial infections is less well understood. Mice lacking the type I IFN receptor (IFNAR-/-) demonstrate enhanced resistance to infection with Listeriamonocytogenes. We have now determined that following infection with Listeria, the composition of innate cells recruited to the peritoneal cavity of IFNAR-/- mice reflects an increase in the frequency of neutrophils and a decrease in monocyte frequency compared to WT controls. These differences in inflammatory infiltrates could not be attributed to distinct bone marrow composition prior to infection or to level of apoptosis. We also observed no differences in neutrophil oxidative burst. However, blocking CXCR2 prevented enhanced neutrophil influx and hampered bacterial clearance. Taken together, these studies highlight a novel mechanism by which type I interferon signaling regulates the immune response to Listeria, through negative regulation of chemokines driving neutrophil recruitment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.