Evidence map›Paper›PMID 22211980›Full record

ArticleAnnals of the New York Academy of Sciences2011

Humanized mice for the study of type 1 and type 2 diabetes.

Dale L Greiner, Michael A Brehm, Vishnu Hosur, David M Harlan, Alvin C Powers, Leonard D Shultz

Abstract read
In one paragraph

Article in Annals of the New York Academy of Sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Port of Choice: Induction Chamber Inlet Position Affects Speed of Isoflurane Induction in Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. De-coding genetic risk variants in type 1 diabetes.Immunology and cell biology · 2021
    Review
  10. Hematopoietic Stem Cells in Type 1 Diabetes.Frontiers in immunology · 2021
    Review
  11. Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  12. Development of Humanized Mice in the Age of Genome Editing.Journal of cellular biochemistry · 2017
    Article
  13. Article
  14. Article
  15. Genetic ablation of lymphocytes and cytokine signaling in nonobese diabetic mice prevents diet-induced obesity and insulin resistance.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016
    Article
  16. Article
  17. Application of Humanized Mice in Immunological Research.Methods in molecular biology (Clifton, N.J.) · 2016
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dale L GreinerUniversity of Massachusetts Medical School, Worcester, Massachusetts, USA. dale.greiner@umassmed.edu
Michael A Brehm
Vishnu Hosur
David M Harlan
Alvin C Powers
Leonard D Shultz

Funding

Coordinating Center for Beta Cell Biology ConsortiumU01DK072473 · NIDDK · VANDERBILT UNIVERSITY · PI MAGNUSON, MARK A · 2005 to 2014
$61.0M
Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3M
TRANSGENIC MOUSE/ ES CELL SHARES RESOURCESP60DK020593 · NIDDK · VANDERBILT UNIVERSITY · PI MCGUINNESS, OWEN P · 1986 to 2011
$28.1M
Virology and Technology CoreP01AI046629 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BREHM, MICHAEL ALLEN · 1999 to 2014
$19.1M
Vanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9M
PILOT AND FEASIBILITY PROGRAMP30DK032520 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CZECH, MICHAEL P · 1986 to 2010
$14.6M
Molecular Mechanisms of Human and Murine Beta Cell Proliferation and RegenerationU01DK089572 · NIDDK · VANDERBILT UNIVERSITY · PI GREINER, DALE LESLIE, HARLAN, DAVID MARSHALL · 2010 to 2014
$8.4M
Vanderbilt Mouse Metabolic Phenotyping CenterU2CDK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2016 to 2021
$6.3M
GLP-1 to Enhance Islet TransplantationR33DK066636 · NIDDK · VANDERBILT UNIVERSITY · PI POWERS, ALVIN C · 2005 to 2007
$1.5M
VEGF and Islet VascularizationR01DK069603 · NIDDK · VANDERBILT UNIVERSITY · PI POWERS, ALVIN C · 2005 to 2010
$1.3M
GLP-1 to Enhance Islet TransplantationR21DK066636 · NIDDK · VANDERBILT UNIVERSITY · PI POWERS, ALVIN CARTER · 2003 to 2004
$722k
Pdx-1 and Maf Proteins in Human IsletsR21DK068854 · NIDDK · VANDERBILT UNIVERSITY · PI POWERS, ALVIN CARTER · 2004 to 2005
$680k
BLRD VA I01 BX000666NIAID NIH HHS AI46629NIAID NIH HHS P01 AI046629NIDDK NIH HHS DK20593NIDDK NIH HHS DK32520NIDDK NIH HHS DK59637NIDDK NIH HHS DK66636NIDDK NIH HHS DK68854NIDDK NIH HHS DK72473NIDDK NIH HHS DK89572NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK032520NIDDK NIH HHS P60 DK020593NIDDK NIH HHS R01 DK069603NIDDK NIH HHS R21 DK066636NIDDK NIH HHS R21 DK068854NIDDK NIH HHS R33 DK066636NIDDK NIH HHS U01 DK072473NIDDK NIH HHS U01 DK089572NIDDK NIH HHS U24 DK059637
6 · The paper itself

Abstract

The availability of immunodeficient mice engrafted with functional human immune systems and islets permits in vivo study of human diabetes without putting patients at risk.

Indexed as

AnimalsDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Disease Models, AnimalHematopoietic Stem Cell TransplantationHLA AntigensHumansHyperglycemiaInterleukin Receptor Common gamma SubunitIslets of Langerhans TransplantationMiceMice, Inbred NODMice, SCIDMice, TransgenicTransplantation, HeterologousHLA AntigensIl2rg protein, mouseInterleukin Receptor Common gamma Subunit

Identifiers

PMID22211980
PMCPMC3384500

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.