Evidence map›Paper›PMID 22211341›Full record

ArticleThe American journal on addictions

Variation in OPRM1 and risk of suicidal behavior in drug-dependent individuals.

Albert J Arias, Grace Chan, Joel Gelernter, Lindsay Farrer, Henry R Kranzler

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal on addictions. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Genetic Vulnerability to Opioid Addiction.Cold Spring Harbor perspectives in medicine · 2021
    Review
  2. Article
  3. Article
  4. The Role of Opiates in Social Pain and Suicidal Behavior.Current topics in behavioral neurosciences · 2020
    Review
  5. Review
  6. Opioid receptor polymorphism A118G associated with clinical severity in a drug overdose population.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Albert J AriasDepartment of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, USA.
Grace Chan
Joel Gelernter
Lindsay Farrer
Henry R Kranzler
VA Connecticut Healthcare System · USBoston Public Schools · USUniversity of Connecticut · US

Funding

Vulnerabilities for coping-related drinking among post-college young adultsP60AA003510 · NIAAA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HESSELBROCK, VICTOR M · 2008 to 2017
$17.5M
Sex-specific analysis of opioid dependence GWAS and beyondR01DA012690 · NIDA · YALE UNIVERSITY · PI GELERNTER, JOEL · 2000 to 2017
$14.0M
WHO COLLABORATIVE PROJECT ON MANAGEMENT OF HARMFUL ALCOHOL CONSUMPTIONP50AA003510 · NIAAA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HESSELBROCK, VICTOR M · 1985 to 2007
$13.6M
GENETICS OF COCAINE DEPENDENCER01DA012849 · NIDA · YALE UNIVERSITY · PI GELERNTER, JOEL · 1999 to 2010
$11.5M
Genetics of Cocaine DependenceR01DA018432 · NIDA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KRANZLER, HENRY RICHARD · 2006 to 2010
$3.5M
Novel Approaches to Alcoholism Pharmacotherapy and RiskK24AA013736 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI KRANZLER, HENRY RICHARD · 2002 to 2012
$1.5M
Alcohol Dependence: Pharmacotherapy, Pharmacogenetics, and GeneticsK23AA017689 · NIAAA · YALE UNIVERSITY · PI ARIAS, ALBERT JOSEPH · 2010 to 2013
$719k
NIAAA NIH HHS K23 AA017689NIAAA NIH HHS K24 AA013736NIAAA NIH HHS K24 AA13736NIAAA NIH HHS P50 AA003510NIAAA NIH HHS P60 AA003510NIAAA NIH HHS P60AA03510NIDA NIH HHS R01 DA012690NIDA NIH HHS R01 DA012849NIDA NIH HHS R01 DA018432NIDA NIH HHS R01 DA12690NIDA NIH HHS R01 DA12849NIDA NIH HHS R01 DA18432
6 · The paper itself

Abstract

Completed suicide and nonfatal suicide-related outcomes (SROs), such as suicidal ideation and attempts, are heritable. A recent genetic association study in a sample of suicide victims reported a protective effect of the G allele of Asn40Asp (rs1799971) on risk for completed suicide. We examined the association of three OPRM1 single nucleotide polymorphisms (SNPs) (rs1799971, rs609148, and rs648893) with SRO in 426 European Americans, using GEE logistic regression analysis to examine the association of a lifetime history of SRO. There was no allelic association with the SRO phenotypes. A larger sample may be needed to identify risk variants that convey SRO risk. OPRM1 may not be important in the risk of SRO.

Indexed as

Substance-Related DisordersSuicidal IdeationAdultDiagnostic and Statistical Manual of Mental DisordersFemaleHumansInterview, PsychologicalMalePolymorphism, Single NucleotideReceptors, Opioid, muRisk FactorsSuicide, AttemptedSynaptic TransmissionOPRM1 protein, humanReceptors, Opioid, mu

Identifiers

PMID22211341
PMCPMC3674102
OpenAlexW1486826263

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.