ArticleIndian journal of clinical biochemistry : IJCB2011
Do over 200 million healthy altitude residents really suffer from chronic Acid-base disorders?
Article in Indian journal of clinical biochemistry : IJCB, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Alterations in acid-base balance and high-intensity exercise performance after short-term and long-term exposure to acute normobaric hypoxic conditions.Scientific reports · 2020Trial
- Trial
- Response to the letter from Bushfield and Day: Potential pitfalls of using a correction to normative values in the assessment of acid-base compensation during early ascent to high altitude.Experimental physiology · 2026Article
- Early acclimatization to high altitude: Acid-base and fluid balance dynamics during the first 2 days at 3100 m.Experimental physiology · 2026Article
- Potential pitfalls of using a correction to normative values for the assessment of acid-base compensation during early ascent to high altitude.Experimental physiology · 2026Article
- Preacclimatization and base excess rather than deficit?Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Reply to Kleinsasser et al.: Superimposed acclimatization and adaptation to low and high altitudes in highlanders compared to lowlanders.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- High altitude impact on serum bicarbonate in healthy Mexican children: concerning the overdiagnosis of renal tubular acidosis.BMC nephrology · 2024Article
- A review of methods for assessment of cognitive function in high-altitude hypoxic environments.Brain and behavior · 2024Review
- Biomarkers as predictors of mortality in critically ill obese patients with COVID-19 at high altitude.BMC pulmonary medicine · 2023Article
- The ultrasound-based cardiac output monitoring is a useful tool to define baseline hemodynamic parameters in healthy permanent residents at high altitude: results of a monocentric pilot study.Frontiers in physiology · 2023Article
- Arterial blood analysis of healthy residents in Huamachuco, Peru (3,164 m): a cross-sectional study.F1000Research · 2023Article
- Oxygen therapy limiting peripheral oxygen saturation to 89-93% is associated with a better survival prognosis for critically ill COVID-19 patients at high altitudes.Respiratory physiology & neurobiology · 2022Observational
- The Oxygen Transport Triad in High-Altitude Pulmonary Edema: A Perspective from the High Andes.International journal of environmental research and public health · 2021Article
- Arterial blood gases and ventilation at rest by age and sex in an adult Andean population resident at high altitude.European journal of applied physiology · 2020Article
- Acid-Base Status Disturbances in Patients on Chronic Hemodialysis at High Altitudes.International journal of nephrology · 2018Article
- Effect of altitude on brain intracellular pH and inorganic phosphate levels.Psychiatry research · 2014Article
- Short-term responses of the kidney to high altitude in mountain climbers.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As the oxygen tension of inspired air falls with increasing altitude in normal subjects, hyperventilation ensues. This acute respiratory alkalosis, induces increased renal excretion of bicarbonate, returning the pH back to normal, giving rise to compensated respiratory alkalosis or chronic hypocapnia. It seems a contradiction that so many normal people at high altitude should permanently live as chronic acid-base patients. Blood gas analyses of 1,865 subjects at 3,510 m, reported a P(a)CO(2) (arterial carbon dioxide tension ± SEM) = 29.4 ± 0.16 mmHg and pH = 7.40 ± 0.005. Base excess, calculated with the Van Slyke sea level equation, is -5 mM (milliMolar or mmol/l) as an average, suggesting chronic hypocapnia. THID, a new term replacing "Base Excess" is determined by titration to a pH of 7.40 at a P(a)CO(2) of 5.33 kPa (40 mmHg) at sea level, oxygen saturated and at 37°C blood temperature. Since our new modified Van Slyke equations operate with normal values for P(a)CO(2) at the actual altitude, a calculation of THID will always result in normal values-that is, zero.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.