ArticleNucleic acids research2012
Determinants of mRNA recognition and translation regulation by Lin28.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Dynamic nucleolar phase separation influenced by non-canonical function of LIN28A instructs pluripotent stem cell fate decisions.Nature communications · 2024Article
- RNA-Binding Proteins in Bladder Cancer.Cancers · 2023Review
- Expression of androgen receptor and its regulatory molecule Lin28 in non-luminal subtype breast cancer.Molecular and clinical oncology · 2020Article
- The RNA-binding protein LIN28 controls progenitor and neuronal cell fate during postnatal neurogenesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Emerging roles of RNA-binding proteins in diabetes and their therapeutic potential in diabetic complications.Wiley interdisciplinary reviews. RNA · 2018Review
- Roles of microRNAs and RNA-Binding Proteins in the Regulation of Colorectal Cancer Stem Cells.Cancers · 2017Review
- A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors.Nature medicine · 2017Article
- Oncogenic mechanisms of Lin28 in breast cancer: new functions and therapeutic opportunities.Oncotarget · 2017Review
- Lin28A activates androgen receptor via regulation of c-myc and promotes malignancy of ER-/Her2+ breast cancer.Oncotarget · 2016Article
- LIN28B suppresses microRNA let-7b expression to promote CD44+/LIN28B+ human pancreatic cancer stem cell proliferation and invasion.American journal of cancer research · 2015Article
- Stepwise assembly of multiple Lin28 proteins on the terminal loop of let-7 miRNA precursors.Nucleic acids research · 2014Article
- Mechanisms of Lin28-mediated miRNA and mRNA regulation--a structural and functional perspective.International journal of molecular sciences · 2013Review
- Lin28 promotes growth of prostate cancer cells and activates the androgen receptor.The American journal of pathology · 2013Article
- Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation.RNA biology · 2013Article
- Identification of mRNAs bound and regulated by human LIN28 proteins and molecular requirements for RNA recognition.RNA (New York, N.Y.) · 2013Article
- Lin28 regulates BMP4 and functions with Oct4 to affect ovarian tumor microenvironment.Cell cycle (Georgetown, Tex.) · 2013Article
- Increased expression of Lin28B associates with poor prognosis in patients with oral squamous cell carcinoma.PloS one · 2013Article
- LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance.Molecular cell · 2012Article
- Drosha mediates destabilization of Lin28 mRNA targets.Cell cycle (Georgetown, Tex.) · 2012Article
- Lin28 and HER2: two stem cell regulators conspire to drive aggressive breast cancer.Cell cycle (Georgetown, Tex.) · 2012Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lin28 is critical for stem cell maintenance and is also associated with advanced human malignancies. Our recent genome-wide studies mark Lin28 as a master post-transcriptional regulator of a subset of messenger RNAs important for cell growth and metabolism. However, the molecular basis underpinning the selective mRNA target regulation is unclear. Here, we provide evidence that Lin28 recognizes a unique motif in multiple target mRNAs, characterized by a small but critical 'A' bulge flanked by two G:C base pairs embedded in a complex secondary structure. This motif mediates Lin28-dependent stimulation of translation. As Lin28 is also known to inhibit the biogenesis of a cohort of miRNAs including let-7, we propose that Lin28 binding to different RNA types (precursor miRNAs versus mRNAs) may facilitate recruitment of different co-factors, leading to distinct regulatory outcomes. Our findings uncover a putative yet unexpected motif that may constitute a mechanistic base for the multitude of functions regulated by Lin28 in both stem cells and cancer cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.