ArticleRheumatology (Oxford, England)2012
Genetic association study of NF-κB genes in UK Caucasian adult and juvenile onset idiopathic inflammatory myopathy.
Article in Rheumatology (Oxford, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Multiple allelic associations from genes involved in energy metabolism were identified in celiac disease.Journal of biosciences · 2021Pooled it
- Genetics of idiopathic inflammatory myopathies: insights into disease pathogenesis.Current opinion in rheumatology · 2019Pooled it
- Associations between TNF-α-308A/G polymorphism and susceptibility with dermatomyositis: a meta-analysis.PloS one · 2014Pooled it
- PTGDR -441 C/T Polymorphism in a Mexican Mestizo Population with Inflammatory Myopathies: A Pilot Study.Current issues in molecular biology · 2026Article
- Identification of hub biomarkers and immune cell infiltration in polymyositis and dermatomyositis.Aging · 2022Article
- Review
- Polymyositis and dermatomyositis - challenges in diagnosis and management.Journal of translational autoimmunity · 2019Article
- Correlation between visual acuity and human leukocyte antigen DRB1*04 in patients with Vogt-Koyanagi-Harada disease.BMC ophthalmology · 2019Article
- Focused HLA analysis in Caucasians with myositis identifies significant associations with autoantibody subgroups.Annals of the rheumatic diseases · 2019Article
- Genetics in inclusion body myositis.Current opinion in rheumatology · 2017Review
- Positive association of genetic variations in the phospholipase C-like 1 gene with dermatomyositis in Chinese Han.Immunologic research · 2016Article
- Role of Jo-1 in the Immunopathogenesis of the Anti-synthetase Syndrome.Current rheumatology reports · 2015Review
- Myositis registries and biorepositories: powerful tools to advance clinical, epidemiologic and pathogenic research.Current opinion in rheumatology · 2014Review
- Genetic association study of TNFAIP3, IFIH1, IRF5 polymorphisms with polymyositis/dermatomyositis in Chinese Han population.PloS one · 2014Article
- Update in juvenile myositis.Current opinion in rheumatology · 2013Review
- Adult and juvenile dermatomyositis: are the distinct clinical features explained by our current understanding of serological subgroups and pathogenic mechanisms?Arthritis research & therapy · 2013Review
- T cells in myositis.Arthritis research & therapy · 2012Review
Corrections and comments
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Authors and funding
13 authors at 8 institutions in 3 countries.
Funding
Abstract
objectiveTreatment-resistant muscle wasting is an increasingly recognized problem in idiopathic inflammatory myopathy (IIM). TNF-α is thought to induce muscle catabolism via activation of nuclear factor-kappa B (NF-κB). Several genes share homology with the NF-κB family of proteins. This study investigated the role of NF-κB-related genes in disease susceptibility in UK Caucasian IIM.
methodsData from 362 IIM cases [274 adults, 49 (±14.0) years, 72% female; 88 juveniles, 6 (±3.6) years, 73% female) were compared with 307 randomly selected Caucasian controls. DNA was genotyped for 63 single nucleotide polymorphisms (SNPs) from NF-κB-related genes. Data were stratified by IIM subgroup/serotype.
resultsA significant allele association was observed in the overall IIM group vs controls for the IKBL-62T allele (rs2071592, odds ratio 1.5, 95% CI 1.21, 1.89, corrected P = 0.0086), which strengthened after stratification by anti-Jo-1 or -PM-Scl antibodies. Genotype analysis revealed an increase for the AT genotype in cases under a dominant model. No other SNP was associated in the overall IIM group. Strong pairwise linkage disequilibrium was noted between IKBL-62T, TNF-308A and HLA-B*08 (D' = 1). Using multivariate regression, the IKBL-62T IIM association was lost after adjustment for TNF-308A or HLA-B*08.
conclusionAn association was noted between IKBL-62T and IIM, with increased risk noted in anti-Jo-1- and -PM-Scl antibody-positive patients. However, the IKBL-62T association is dependent on TNF-308A and HLA-B*08, due to strong shared linkage disequilibrium between these alleles. After adjustment of the 8.1 HLA haplotype, NF-κB genes therefore do not independently confer susceptibility in IIM.
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Registered trials
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