ArticleDiabetes2012
Glucocorticoid signaling in the arcuate nucleus modulates hepatic insulin sensitivity.
Article in Diabetes, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 68 citations in OpenAlex.
- Hypothalamus-Peripheral Organ Crosstalk in Energy Metabolism: A Bidirectional Regulatory Network.Endocrinology and metabolism (Seoul, Korea) · 2026Review
- Consensus on the key characteristics of metabolism disruptors.Nature reviews. Endocrinology · 2025Review
- Brain-Body Communication in Glucose Metabolism.Advances in experimental medicine and biology · 2025Review
- Hypothalamus-sympathetic-liver axis mediates the early phase of stress-induced hyperglycemia in the male mice.Nature communications · 2024Article
- Fresh insights into glucocorticoid-induced diabetes mellitus and new therapeutic directions.Nature reviews. Endocrinology · 2022Review
- Avian Neuropeptide Y: Beyond Feed Intake Regulation.Veterinary sciences · 2022Review
- Lifestyle interventions for the prevention and treatment of hypertension.Nature reviews. Cardiology · 2021Review
- Glucose metabolism in Cushing's syndrome.Current opinion in endocrinology, diabetes, and obesity · 2020Review
- Preventive Effects of Schisandrin A, A Bioactive Component ofNutrients · 2020Article
- Zinc Finger Transcription Factor Zbtb16 Coordinates the Response to Energy Deficit in the Mouse Hypothalamus.Frontiers in neuroscience · 2020Article
- Amelioration of muscle wasting by glucagon-like peptide-1 receptor agonist in muscle atrophy.Journal of cachexia, sarcopenia and muscle · 2019 · on this mapArticle
- Metabolic Abnormalities of Chronic High-Dose Glucocorticoids Are Not Mediated by Hypothalamic AgRP in Male Mice.Endocrinology · 2019Article
- FGF21 regulates insulin sensitivity following long-term chronic stress.Molecular metabolism · 2018Article
- Catecholaminergic projections into an interconnected forebrain network control the sensitivity of male rats to diet-induced obesity.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Interactions of Circadian Rhythmicity, Stress and Orexigenic Neuropeptide Systems: Implications for Food Intake Control.Frontiers in neuroscience · 2017Review
- Stress-induced alterations in estradiol sensitivity increase risk for obesity in women.Physiology & behavior · 2016Review
- Epigenomic and transcriptional control of insulin resistance.Journal of internal medicine · 2016Review
- Neuroinflammatory and autonomic mechanisms in diabetes and hypertension.American journal of physiology. Endocrinology and metabolism · 2016Review
- Nuclear Mechanisms of Insulin Resistance.Trends in cell biology · 2016Review
- Hypothalamic-autonomic control of energy homeostasis.Endocrine · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucocorticoid receptors are highly expressed in the hypothalamic paraventricular nucleus (PVN) and arcuate nucleus (ARC). As glucocorticoids have pronounced effects on neuropeptide Y (NPY) expression and as NPY neurons projecting from the ARC to the PVN are pivotal for balancing feeding behavior and glucose metabolism, we investigated the effect of glucocorticoid signaling in these areas on endogenous glucose production (EGP) and insulin sensitivity by local retrodialysis of the glucocorticoid receptor agonist dexamethasone into the ARC or the PVN, in combination with isotope dilution and hyperinsulinemic-euglycemic clamp techniques. Retrodialysis of dexamethasone for 90 min into the ARC or the PVN did not have significant effects on basal plasma glucose concentration. During the hyperinsulinemic-euglycemic clamp, retrodialysis of dexamethasone into the ARC largely prevented the suppressive effect of hyperinsulinemia on EGP. Antagonizing the NPY1 receptors by intracerebroventricular infusion of its antagonist largely blocked the hepatic insulin resistance induced by dexamethasone in the ARC. The dexamethasone-ARC-induced inhibition of hepatic insulin sensitivity was also prevented by hepatic sympathetic denervation. These data suggest that glucocorticoid signaling specifically in the ARC neurons modulates hepatic insulin responsiveness via NPY and the sympathetic system, which may add to our understanding of the metabolic impact of clinical conditions associated with hypercortisolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.