ArticleMolecules (Basel, Switzerland)2011
Inhibition of sevoflurane postconditioning against cerebral ischemia reperfusion-induced oxidative injury in rats.
Article in Molecules (Basel, Switzerland), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Anesthetic gas sevoflurane postconditioning alleviates cognitive impairment induced by hemorrhagic shock and resuscitation.Medical gas research · 2026Article
- Article
- Sevoflurane Postconditioning Attenuates Hepatic Ischemia-Reperfusion Injury by Limiting HMGB1/TLR4/NF-κB PathwayFrontiers in pharmacology · 2021Article
- Comparison of the Effects of Sevoflurane and Desflurane on Thiol-Disulfide Homeostasis in Patients Undergoing Laparoscopic Cholecystectomy.The Eurasian journal of medicine · 2019Article
- Neuroprotective Effects and Mechanisms of Zhenlong Xingnao Capsule inFrontiers in pharmacology · 2019Article
- The Orally Active Noncompetitive AMPAR Antagonist Perampanel Attenuates Focal Cerebral Ischemia Injury in Rats.Cellular and molecular neurobiology · 2018Article
- The effect of pre- and after-treatment of sevoflurane on central ischemia tolerance and the underlying mechanisms.Journal of dental anesthesia and pain medicine · 2018Review
- Ischemic Tolerance of the Brain and Spinal Cord: A Review.Neurologia medico-chirurgica · 2017Review
- Immune Modulation by Volatile Anesthetics.Anesthesiology · 2016Review
- Neuroprotection of Sevoflurane Against Ischemia/Reperfusion-Induced Brain Injury Through Inhibiting JNK3/Caspase-3 by Enhancing Akt Signaling Pathway.Molecular neurobiology · 2016Article
- In Vitro Induction of Endothelial Apoptosis of the Post-Hypoxic Blood-Brain Barrier by Isoflurane but Not by Sevoflurane and Midazolam.PloS one · 2015Article
- Synergistic white matter protection with acute-on-chronic endotoxin and subsequent asphyxia in preterm fetal sheep.Journal of neuroinflammation · 2014Article
- Article
- Isoflurane postconditioning reduces ischemia-induced nuclear factor-κB activation and interleukin 1β production to provide neuroprotection in rats and mice.Neurobiology of disease · 2013Article
- Effects of sevoflurane postconditioning on cell death, inflammation and TLR expression in human endothelial cells exposed to LPS.Journal of translational medicine · 2013Article
- Biological networks in ischemic tolerance - rethinking the approach to clinical conditioning.Translational stroke research · 2013Review
- Synthesis and protective effect of scutellarein on focal cerebral ischemia/reperfusion in rats.Molecules (Basel, Switzerland) · 2012Article
- Developing a standardized system of exposure and intervention endpoints for isoflurane in preclinical stroke models.Medical gas researchReview
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The volatile anesthetic sevoflurane is capable of inducing preconditioning and postconditioning effects in the brain. In this study, we investigated the effects of sevoflurane postconditioning on antioxidant and immunity indexes in cerebral ischemia reperfusion (CIR) rats. Rats were randomly assigned to five separate experimental groups I-V. In the sham group (I), rats were subjected to the same surgery procedures except for occlusion of the middle cerebral artery and exposed to 1.0 MAC sevoflurane 90 min after surgery for 30 min. IR control rats (group II) were subjected to middle cerebral artery occlusion (MCAO) for 90 min and exposed to O₂ for 30 min at the beginning of reperfusion. Sevoflurane 0.5, 1.0 and 1.5 groups (III, IV, V) were all subjected to MCAO for 90 min, but at the beginning of reperfusion exposed to 0.5 MAC, 1.0 MAC or 1.5 MAC sevoflurane for 30 min, respectively. Results showed that sevoflurane postconditioning can decrease serum tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), nitric oxide (NO), nitric oxide synthase (NOS) and increase serum interleukin-10 (IL-10) levels in cerebral ischemia reperfusion rats. In addition, sevoflurane postconditioning can still decrease blood lipid, malondialdehyde (MDA) levels, infarct volume and increase antioxidant enzymes activities, normal pyramidal neurons density in cerebral ischemia reperfusion rats. It can be concluded that sevoflurane postconditioning may decrease blood and brain oxidative injury and enhance immunity indexes in cerebral ischemia reperfusion rats.
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