ArticleMolecules (Basel, Switzerland)2011
Neuroprotective effects of exogenous activin A on oxygen-glucose deprivation in PC12 cells.
Article in Molecules (Basel, Switzerland), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Harpagide attenuates cerebral ischemic injury by modulating mitochondrial calcium homeostasis associated with the AMPK-MCU axis.Scientific reports · 2026Article
- Brain Damage in Preterm and Full-Term Neonates: Serum Biomarkers for the Early Diagnosis and Intervention.Antioxidants (Basel, Switzerland) · 2023Review
- Local Immunomodulation with Anti-inflammatory Cytokine-Encoding Lentivirus Enhances Functional Recovery after Spinal Cord Injury.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- Activin receptors regulate the oligodendrocyte lineage in health and disease.Acta neuropathologica · 2018Article
- Neuroprotective Effects of Bioactive Compounds and MAPK Pathway Modulation in "Ischemia"-Stressed PC12 Pheochromocytoma Cells.Brain sciences · 2018Review
- Research Progress on the Role and Mechanism of Action of Activin A in Brain Injury.Frontiers in neuroscience · 2018Review
- Neuroprotective effects of Activin A on endoplasmic reticulum stress-mediated apoptotic and autophagic PC12 cell death.Neural regeneration research · 2017Article
- Extract of Spatholobus suberctus Dunn ameliorates ischemia-induced injury by targeting miR-494.PloS one · 2017Article
- Noncanonical Activin A Signaling in PC12 Cells: A Self-Limiting Feedback Loop.Neurochemical research · 2016Article
- Mesenchymal stem cells suppress neuronal apoptosis and decrease IL-10 release via the TLR2/NFκB pathway in rats with hypoxic-ischemic brain damage.Molecular brain · 2015Article
- Neuroprotective effect of schizandrin A on oxygen and glucose deprivation/reperfusion-induced cell injury in primary culture of rat cortical neurons.Journal of physiology and biochemistry · 2014Article
- Article
- Endogenous protection derived from activin A/Smads transduction loop stimulated via ischemic injury in PC12 cells.Molecules (Basel, Switzerland) · 2013Article
- M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination.Nature neuroscience · 2013Article
- Effects of SARA on oxygen-glucose deprivation in PC12 cell line.Neurochemical research · 2013Article
- Biomarkers of brain injury in the premature infant.Frontiers in neurology · 2012Article
- rLj-RGD3, a Novel Three-RGD-Motif-Containing Recombinant Protein fromBioMed research internationalArticle
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ischemic cerebrovascular disease is one of the most common causes of death in the World. Exogenous activin A (ActA) protects neurons against toxicity and plays a central role in regulating the brain's response to injury. In the present study, we investigated the mechanisms involved in the neuroprotective effects of ActA in a model of hypoxic-ischemic brain disease. We found that ActA could effectively increase the survival rate of PC12 cells and relieve oxygen-glucose deprivation (OGD) damage. To clarify the neuroprotective mechanisms of ActA, the effects of ActA on the ActA/Smad pathway and on the up-regulation of inducible nitric oxide synthase (NOS) and superoxide dismutase (SOD) were investigated using OGD in PC12 cells. The results showed that ActA could increase the expression of activin receptor IIA (ActRIIA), Smad3 and Smad4 and that 50 ng/mL and 100 ng/mL of ActA could reduce NO levels and increase SOD activity by 78.9% and 79.9%, respectively. These results suggested that the neuroprotective effects of ActA in ischemia could be related to the activation of the ActA/Smad signaling pathway and to its anti-oxidant activities.
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