ArticleThe American journal of pathology1990
Megakaryocyte synthesis is the source of epidermal growth factor in human platelets.
Article in The American journal of pathology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 73 citations in OpenAlex.
- Platelets: the first cellular responders in the foreign body response to blood-contacting biomaterials.Frontiers in immunology · 2026Review
- Intraovarian injection of platelet-rich plasma in assisted reproduction: too much too soon?Human reproduction (Oxford, England) · 2021Article
- Large granular lymphocyte leukemia serum and corresponding hematological parameters reveal unique cytokine and sphingolipid biomarkers and associations with STAT3 mutations.Cancer medicine · 2020Article
- Platelets and Metastasis: New Implications of an Old Interplay.Frontiers in oncology · 2020Review
- Unfractionated and Low Molecular Weight Heparin Reduce Platelet Induced Epithelial-Mesenchymal Transition in Pancreatic and Prostate Cancer Cells.Molecules (Basel, Switzerland) · 2018Article
- Role of platelets and platelet receptors in cancer metastasis.Journal of hematology & oncology · 2018Review
- Epidermal Growth Factor (EGF) Autocrine Activation of Human Platelets Promotes EGF Receptor-Dependent Oral Squamous Cell Carcinoma Invasion, Migration, and Epithelial Mesenchymal Transition.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Clinical and Biological Correlates of Neurotoxicity Associated with CAR T-cell Therapy in Patients with B-cell Acute Lymphoblastic Leukemia.Cancer discovery · 2018Article
- Ticagrelor Improves Endothelial Function by Decreasing Circulating Epidermal Growth Factor (EGF).Frontiers in physiology · 2018Article
- Deciphering Platelet Kinetics in Diagnostic and Prognostic Evaluation of Hepatocellular Carcinoma.Canadian journal of gastroenterology & hepatology · 2018Review
- The soluble protease ADAMDEC1 released from activated platelets hydrolyzes platelet membrane pro-epidermal growth factor (EGF) to active high-molecular-weight EGF.The Journal of biological chemistry · 2017Article
- Beyond Clotting: A Role of Platelets in CNS Repair?Frontiers in cellular neuroscience · 2015Article
- A histological and micro-CT investigation in to the effect of NGF and EGF on the periodontal, alveolar bone, root and pulpal healing of replanted molars in a rat model - a pilot study.Progress in orthodontics · 2014Article
- Decreased plasma cytokines are associated with low platelet counts in aplastic anemia and immune thrombocytopenic purpura.Journal of thrombosis and haemostasis : JTH · 2012Article
- Differential effects of tumor-platelet interaction in vitro and in vivo in glioblastoma.Journal of neuro-oncology · 2011Article
- Protease-activated receptors in cancer: A systematic review.Oncology letters · 2011Article
- Platelet granule secretion continuously prevents intratumor hemorrhage.Cancer research · 2008Article
- Article
- Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- The hemostatic system and angiogenesis in malignancy.Neoplasia (New York, N.Y.)Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Epidermal growth factor (EGF) is known to be present in the alpha granules of human platelets; however the source of this EGF, ie, whether it is taken up by the platelets from the circulation, or whether it is packaged into the platelets from the megakaryocyte during thrombopoiesis, is unknown. To determine whether EGF is taken up by platelets, platelets for EGF receptors were assayed and it was attempted to detect uptake of EGF by the platelets from culture medium. Platelets were found to lack EGF receptors, and no uptake of EGF from the culture medium was detected. To assess whether EGF is packaged into platelets from the megakaryocyte, megakaryocytes in frozen section bone marrow cores were stained for EGF protein by immunohistochemistry, and it was demonstrated that EGF is present in megakaryocytes. In addition, staining of megakaryocytes by in situ hybridization for EGF mRNA demonstrated its presence in these cells. Therefore it is concluded that the source of EGF in human platelets is the megakaryocyte and that this EGF is synthesized in the megakaryocyte rather than being taken up from its environment.
Indexed as
Identifiers
2221009PMC1877562W36192329What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.