ArticleDevelopmental biology2012
Zinc finger homeobox is required for the differentiation of serotonergic neurons in the sea urchin embryo.
Article in Developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 40 citations in OpenAlex.
- An Integrated Canonical and Non-Canonical Wnt Signaling Network Controls Early Anterior-Posterior Axis Formation in Sea Urchin Embryos.Journal of developmental biology · 2025Review
- Characterization of Maturation-Associated Genes in Ovary-Hepatopancreas Transcriptome andAnimals : an open access journal from MDPI · 2025Article
- Anterior-Posterior Wnt Signaling Network Conservation between Indirect Developing Sea Urchin and Hemichordate Embryos.Integrative and comparative biology · 2024Article
- Evolution and Function of the Notch Signaling Pathway: An Invertebrate Perspective.International journal of molecular sciences · 2024Review
- Transcription of microRNAs is regulated by developmental signaling pathways and transcription factors.Frontiers in cell and developmental biology · 2024Article
- microRNA-124 regulates Notch and NeuroD1 to mediate transition states of neuronal development.Developmental neurobiology · 2023Article
- Rx and its downstream factor, Musashi1, is required for establishment of the apical organ in sea urchin larvae.Frontiers in cell and developmental biology · 2023Article
- Homologous gene regulatory networks control development of apical organs and brains in Bilateria.Science advances · 2022Article
- Development of a larval nervous system in the sea urchin.Current topics in developmental biology · 2022Review
- Developmental origin of peripheral ciliary band neurons in the sea urchin embryo.Developmental biology · 2020Article
- Evolution of nitric oxide regulation of gut function.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Spatial and temporal patterns of gene expression during neurogenesis in the sea urchinEvoDevo · 2019Article
- Neurogenesis in the sea urchin embryo is initiated uniquely in three domains.Development (Cambridge, England) · 2018Article
- Identification of neural transcription factors required for the differentiation of three neuronal subtypes in the sea urchin embryo.Developmental biology · 2018Article
- Notch-mediated lateral inhibition is an evolutionarily conserved mechanism patterning the ectoderm in echinoids.Development genes and evolution · 2018Article
- A key role forDevelopment (Cambridge, England) · 2017Article
- An anterior signaling center patterns and sizes the anterior neuroectoderm of the sea urchin embryo.Development (Cambridge, England) · 2016Article
- Cooperative Wnt-Nodal Signals Regulate the Patterning of Anterior Neuroectoderm.PLoS genetics · 2016Article
- Neurogenic gene regulatory pathways in the sea urchin embryo.Development (Cambridge, England) · 2016Article
- Mesomere-derived glutamate decarboxylase-expressing blastocoelar mesenchyme cells of sea urchin larvae.Biology open · 2014Article
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4 authors at 2 institutions in 2 countries.
Funding
Abstract
Serotonergic neurons differentiate in the neurogenic animal plate ectoderm of the sea urchin embryo. The regulatory mechanisms that control the specification or differentiation of these neurons in the sea urchin embryo are not yet understood, although, after the genome was sequenced, many genes encoding transcription factors expressed in this region were identified. Here, we report that zinc finger homeobox (zfhx1/z81) is expressed in serotonergic neural precursor cells, using double in situ hybridization screening with a serotonergic neural marker, tryptophan 5-hydroxylase (tph) encoding a serotonin synthase that is required for the differentiation of serotonergic neurons. zfhx1/z81 begins to be expressed at gastrula stage in individual cells in the anterior neuroectoderm, some of which also express delta. zfhx1/z81 expression gradually disappears as neural differentiation begins with tph expression. When the translation of Zfhx1/Z81 is blocked by morpholino injection, embryos express neither tph nor the neural marker synaptotagminB in cells of the animal plate, and serotonergic neurons do not differentiate. In contrast, Zfhx1/Z81 morphants do express fez, another neural precursor marker, which appears to function in the initial phase of specification/differentiation of serotonergic neurons. In addition, zfhx1/z81 is one of the targets suppressed in the animal plate by anti-neural signals such as Nodal as well as Delta-Notch. We conclude that Zfhx1/Z81 functions during the specification of individual anterior neural precursors and promotes the expression of tph and synaptotagminB, required for the differentiation of serotonergic neurons.
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