ArticleGenetics2012
Ecological genomics of Anopheles gambiae along a latitudinal cline: a population-resequencing approach.
Article in Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.
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101 citing papers in PubMed, 204 citations in OpenAlex.
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- When South Meets North: A Joint Contact Zone Coinciding With Environmental Gradients in Three Boreal Tree Species.Molecular ecology · 2026Article
- Spatial distribution of the 2La chromosomal inversion in Anopheles gambiae populations across Nigeria: ecological associations and implications for malaria control.Tropical medicine and health · 2026Article
- Parallel clines of chromosomal inversion frequencies in seaweed flies are associated with thermal variation.Heredity · 2026Article
- Genetic divergence and lower frequencies of insecticide resistance markers in the novel Anopheles gambiae Bissau molecular form in The Gambia.Scientific reports · 2026Article
- Latitudinal Clines in Climate and Sleep Patterns Shape Disease Outcomes inEcology and evolution · 2025Article
- Fusion, fission, and scrambling of the bilaterian genome in Bryozoa.Genome research · 2025Article
- Evolutionary adaptation under climate change:Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Fitness consequences of structural variation inferred from a House Finch pangenome.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Genomics of natural populations: gene conversion events reveal selected genes within the inversions of Drosophila pseudoobscura.G3 (Bethesda, Md.) · 2024Article
- Evolutionary adaptation under climate change:bioRxiv : the preprint server for biology · 2024Article
- Mitochondrial Variation in Anopheles gambiae and Anopheles coluzzii: Phylogeographic Legacy and Mitonuclear Associations With Metabolic Resistance to Pathogens and Insecticides.Genome biology and evolution · 2024Article
- Locally adaptive inversions in structured populations.Genetics · 2024Article
- Evolution of Chromosomal Inversions across an Avian Radiation.Molecular biology and evolution · 2024Article
- Signatures of adaptation at key insecticide resistance loci in Anopheles gambiae in Southern Ghana revealed by reduced-coverage WGS.Scientific reports · 2024Article
- Speciation within theResearch square · 2024Article
- Genetic structure and Rickettsia infection rates in Ixodes ovatus and Haemaphysalis flava ticks across different altitudes.PloS one · 2024Article
- A novel tetra-primer ARMS-PCR approach for the molecular karyotyping of chromosomal inversion 2Ru in the main malaria vectors Anopheles gambiae and Anopheles coluzzii.Parasites & vectors · 2023Article
- Article
41 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The association between fitness-related phenotypic traits and an environmental gradient offers one of the best opportunities to study the interplay between natural selection and migration. In cases in which specific genetic variants also show such clinal patterns, it may be possible to uncover the mutations responsible for local adaptation. The malaria vector, Anopheles gambiae, is associated with a latitudinal cline in aridity in Cameroon; a large inversion on chromosome 2L of this mosquito shows large differences in frequency along this cline, with high frequencies of the inverted karyotype present in northern, more arid populations and an almost complete absence of the inverted arrangement in southern populations. Here we use a genome resequencing approach to investigate patterns of population divergence along the cline. By sequencing pools of individuals from both ends of the cline as well as in the center of the cline- where the inversion is present in intermediate frequency- we demonstrate almost complete panmixia across collinear parts of the genome and high levels of differentiation in inverted parts of the genome. Sequencing of separate pools of each inversion arrangement in the center of the cline reveals large amounts of gene flux (i.e., gene conversion and double crossovers) even within inverted regions, especially away from the inversion breakpoints. The interplay between natural selection, migration, and gene flux allows us to identify several candidate genes responsible for the match between inversion frequency and environmental variables. These results, coupled with similar conclusions from studies of clinal variation in Drosophila, point to a number of important biological functions associated with local environmental adaptation.
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