ArticleMetabolism: clinical and experimental2012
Diurnal salivary cortisol and urinary catecholamines are associated with diabetes mellitus: the Multi-Ethnic Study of Atherosclerosis.
Article in Metabolism: clinical and experimental, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Individual differences in glucocorticoid regulation: Does it relate to disease risk and resilience?Frontiers in neuroendocrinology · 2020Pooled it
- Pooled it
- Disruption of multisystem responses to stress in type 2 diabetes: investigating the dynamics of allostatic load.Proceedings of the National Academy of Sciences of the United States of America · 2014Trial
- Food insecurity in the development of metabolic diseases.Nature reviews. Endocrinology · 2026Review
- Exploring potential diagnostic markers and therapeutic targets for type 2 diabetes mellitus with major depressive disorder through bioinformatics and in vivo experiments.Scientific reports · 2025Article
- Review
- Food insecurity, poor diet, and metabolic measures: The roles of stress and cortisol.Appetite · 2024Article
- Relationship between cortisol and diabetic microvascular complications: a retrospective study.European journal of medical research · 2023Article
- A diabetes-like biochemical and behavioural phenotype ofProceedings. Biological sciences · 2023Article
- Mild to Moderate Sleep Restriction Does Not Affect the Cortisol Awakening Response in Healthy Adult Males.Clocks & sleep · 2022Article
- Glucocorticoid Receptor Signaling in Diabetes.International journal of molecular sciences · 2021Review
- Chronic Inflammation Mediates the Association between Cortisol and Hyperglycemia: Findings from the Cross-Sectional Population-Based KORA Age Study.Journal of clinical medicine · 2021Article
- Disruption of the Diurnal Cortisol Hormone Pattern by Pesticide Use in a Longitudinal Study of Farmers in Thailand.Annals of work exposures and health · 2021Article
- Insufficient glucocorticoid receptor signaling and flattened salivary cortisol profile are associated with metabolic and inflammatory indices in type 2 diabetes.Journal of endocrinological investigation · 2021Article
- The association of cortisol curve features with incident diabetes among whites and African Americans: The CARDIA study.Psychoneuroendocrinology · 2021Article
- The longitudinal association of changes in diurnal cortisol features with fasting glucose: MESA.Psychoneuroendocrinology · 2020Article
- The relationship between sleep problems and cortisol in people with type 2 diabetes.Psychoneuroendocrinology · 2020Article
- Cardiovascular Disease and Hair Cortisol: a Novel Biomarker of Chronic Stress.Current cardiology reports · 2019Review
- The association of morning serum cortisol with glucose metabolism and diabetes: The Jackson Heart Study.Psychoneuroendocrinology · 2019Article
- Gender-Specific Independent and Combined Effects of the Cortisol-to-Cortisone Ratio and 11-Deoxycortisol on Prediabetes and Type 2 Diabetes Mellitus: From the Henan Rural Cohort Study.Journal of diabetes research · 2019Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
The objective was to examine the cross-sectional association of diurnal salivary cortisol curve components and urinary catecholamines with diabetes status. Up to 18 salivary cortisol samples over 3 days and overnight urinary catecholamines were collected from 1002 participants in the Multi-Ethnic Study of Atherosclerosis. Diabetes was defined as a fasting blood glucose of at least 126 mg/dL or medication use. Cortisol curve measures included awakening cortisol, cortisol awakening response, early decline, late decline, and cortisol area under the curve (AUC). Urinary catecholamines included epinephrine, norepinephrine, and dopamine. Participants with diabetes had significantly lower cortisol awakening response (β = -0.19; 95% confidence interval [CI], -0.34 to -0.04) than those without diabetes in multivariable models. Whereas men with diabetes had a nonsignificant trend toward lower total AUC (β = -1.56; 95% CI, -3.93 to 0.80), women with diabetes had significantly higher total AUC (β = 2.62; 95% CI, 0.72 to 4.51) (P = .02 for interaction) compared with those without diabetes. Men but not women with diabetes had significantly lower urinary catecholamines compared with those without diabetes (P < .05). Diabetes is associated with neuroendocrine dysregulation, which may differ by sex. Further studies are needed to determine the role of the neuroendocrine system in the pathophysiology of diabetes.
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Registered trials
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