Evidence map›Paper›PMID 22209327›Full record

ReviewEpilepsy & behavior : E&B2012

Neuroimaging of frontal-limbic dysfunction in schizophrenia and epilepsy-related psychosis: toward a convergent neurobiology.

Tracy Butler, Daniel Weisholtz, Nancy Isenberg, Elizabeth Harding, Jane Epstein, Emily Stern, David Silbersweig

Open access · greenAbstract readReview
In one paragraph

Review in Epilepsy & behavior : E&B, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 58 citations in OpenAlex.

  1. Frontal Disorders and Consciousness: A Review.Current neurology and neuroscience reports · 2025
    Review
  2. Article
  3. Article
  4. Psychiatric features in NMDAR and LGI1 antibody-associated autoimmune encephalitis.European archives of psychiatry and clinical neuroscience · 2024
    Article
  5. Article
  6. GL-II-73, a Positive Allosteric Modulator of α5GABAInternational journal of molecular sciences · 2023
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Neuroinflammation and psychiatric illness.Journal of neuroinflammation · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Tracy ButlerNYU Comprehensive Epilepsy Center, Department of Neurology, New York University School of Medicine, New York, NY, USA. Tracy.butler@nyumc.org
Daniel Weisholtz
Nancy Isenberg
Elizabeth Harding
Jane Epstein
Emily Stern
David Silbersweig
Brigham and Women's Hospital · USHarvard University · USNew York University · US

Funding

Probing Systems-Level Function of Fronto-TemporalP50MH058911 · NIMH · NEW YORK UNIVERSITY · PI LEDOUX, JOSEPH E · 1999 to 2008
$19.4M
fMRI Localization of Psychotic Symptoms in SchizophreniaR01MH061825 · NIMH · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI SILBERSWEIG, DAVID A · 2002 to 2005
$1.2M
Imaging inflammation in focal epilepsyK23NS057579 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI BUTLER, TRACY A. · 2008 to 2012
$887k
NIMH NIH HHS P50MH058911NIMH NIH HHS R01MH061825NINDS NIH HHS K23 NS057579NINDS NIH HHS K23NS057579
6 · The paper itself

Abstract

Psychosis is a devastating, prevalent condition considered to involve dysfunction of frontal and medial temporal limbic brain regions as key nodes in distributed brain networks involved in emotional regulation. The psychoses of epilepsy represent an important, though understudied, model relevant to understanding the pathophysiology of psychosis in general. In this review, we (1) discuss the classification of epilepsy-related psychoses and relevant neuroimaging and other studies; (2) review structural and functional neuroimaging studies of schizophrenia focusing on evidence of frontal-limbic dysfunction; (3) report our laboratory's PET, fMRI, and electrophysiological findings; (4) describe a theoretical framework in which frontal hypoactivity and intermittent medial temporal hyperactivity play a critical role in the etiopathology of psychosis both associated and unassociated with epilepsy; and (5) suggest avenues for future research.

Indexed as

NeuroimagingEpilepsyFrontal LobeHumansLimbic SystemNeural PathwaysPsychotic DisordersSchizophrenia

Identifiers

PMID22209327
PMCPMC3339259
OpenAlexW2120603554

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.