ArticleJournal of biomechanics2012
Mechanical changes in the rat right ventricle with decellularization.
Article in Journal of biomechanics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Full-field analysis indicates late reperfusion therapy broadens and mechanically smooths the borderzone during post-infarction inflammation.Acta biomaterialia · 2026Article
- Ovarian hormones attenuate right ventricular remodeling in a rat model of pulmonary arterial hypertension.Biomechanics and modeling in mechanobiology · 2025Article
- Decellularized Porcine Aorta as a Scaffold for Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells in Tissue Engineering.Stem cell reviews and reports · 2025Article
- Full-Field Assessment of Geometry and Collagenous Architecture of Porcine Valve Leaflets via Laser Micrometry and Quantitative Polarized Light Imaging.Journal of biophotonics · 2025Article
- Passive biaxial mechanical properties of sheep myocardium.Frontiers in bioengineering and biotechnology · 2025Article
- Recent advances in soluble decellularized extracellular matrix for heart tissue engineering and organ modeling.Journal of biomaterials applications · 2023Review
- Don't go breakin' my heart: cardioprotective alterations to the mechanical and structural properties of reperfused myocardium during post-infarction inflammation.Biophysical reviews · 2023Review
- Whole-Heart Tissue Engineering and Cardiac Patches: Challenges and Promises.Bioengineering (Basel, Switzerland) · 2023Review
- Alterations of biaxial viscoelastic properties of the right ventricle in pulmonary hypertension development in rest and acute stress conditions.Frontiers in bioengineering and biotechnology · 2023Article
- Multiscale Contrasts Between the Right and Left Ventricle Biomechanics in Healthy Adult Sheep and Translational Implications.Frontiers in bioengineering and biotechnology · 2022Article
- Characterizing Tissue Remodeling and Mechanical Heterogeneity in Cerebral Aneurysms.Journal of vascular research · 2022Article
- Passive myocardial mechanical properties: meaning, measurement, models.Biophysical reviews · 2021Review
- Mechanical Response Changes in Porcine Tricuspid Valve Anterior Leaflet Under Osmotic-Induced Swelling.Bioengineering (Basel, Switzerland) · 2019Article
- Cardiac tissue-derived extracellular matrix scaffolds for myocardial repair: advantages and challenges.Regenerative biomaterials · 2019Review
- Failure of the Porcine Ascending Aorta: Multidirectional Experiments and a Unifying Microstructural Model.Journal of biomechanical engineering · 2017Article
- Characterizing white matter tissue in large strain via asymmetric indentation and inverse finite element modeling.Journal of the mechanical behavior of biomedical materials · 2017Article
- A nonlinear anisotropic inverse method for computational dissection of inhomogeneous planar tissues.Computer methods in biomechanics and biomedical engineering · 2016Article
- Impact of decellularization on porcine myocardium as scaffold for tissue engineered heart tissue.Journal of materials science. Materials in medicine · 2016Article
- Current achievements and future perspectives in whole-organ bioengineering.Stem cell research & therapy · 2015Review
- Role played by Prx1-dependent extracellular matrix properties in vascular smooth muscle development in embryonic lungs.Pulmonary circulation · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The stiffness, anisotropy, and heterogeneity of freshly dissected (control) and perfusion-decellularized rat right ventricles were compared using an anisotropic inverse mechanics method. Cruciform tissue samples were speckled and then tested under a series of different biaxial loading configurations with simultaneous force measurement on all four arms and displacement mapping via image correlation. Based on the displacement and force data, the sample was segmented into piecewise homogeneous partitions. Tissue stiffness and anisotropy were characterized for each partition using a large-deformation extension of the general linear elastic model. The perfusion-decellularized tissue had significantly higher stiffness than the control, suggesting that the cellular contribution to stiffness, at least under the conditions used, was relatively small. Neither anisotropy nor heterogeneity (measured by the partition standard deviation of the modulus and anisotropy) varied significantly between control and decellularized samples. We thus conclude that although decellularization produces quantitative differences in modulus, decellularized tissue can provide a useful model of the native tissue extracellular matrix. Further, the large-deformation inverse method presented herein can be used to characterize complex soft tissue behaviors.
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Registered trials
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