ReviewVeterinary immunology and immunopathology2012
Crohn's disease and Mycobacterium avium subsp. paratuberculosis: the need for a study is long overdue.
Review in Veterinary immunology and immunopathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Bioprospective Role ofMolecules (Basel, Switzerland) · 2023Review
- Differential Responses of Digesta- and Mucosa-Associated Jejunal Microbiota of Hu Sheep to Pelleted and Non-Pelleted High-Grain Diets.Animals : an open access journal from MDPI · 2022Article
- Seroprevalence of Immunoglobulin G Antibodies AgainstVeterinary sciences · 2020Article
- Characteristics and Epidemiological Investigation of Paratuberculosis in Dairy Cattle in Tai'an, China.BioMed research international · 2020Article
- Cows Get Crohn's Disease and They're Giving Us Diabetes.Microorganisms · 2019Article
- Streptococcus Salivarius: A Potential Salivary Biomarker for Orofacial Granulomatosis and Crohn's Disease?Inflammatory bowel diseases · 2019Article
- Pathogenesis, Molecular Genetics, and Genomics ofFrontiers in veterinary science · 2017Review
- Anaerobic adaptation ofGut pathogens · 2017Article
- On deaf ears, Mycobacterium avium paratuberculosis in pathogenesis Crohn's and other diseases.World journal of gastroenterology · 2015Review
- The impact of primary and persistent cytomegalovirus infection on the progression of acute colitis in a murine model.Pathophysiology : the official journal of the International Society for Pathophysiology · 2015Article
- Mycobacterium paratuberculosis as a cause of Crohn's disease.Expert review of gastroenterology & hepatology · 2015Review
- Analysis of the Bovine Monocyte-Derived Macrophage Response to Mycobacterium avium Subspecies Paratuberculosis Infection Using RNA-seq.Frontiers in immunology · 2015Article
- Mycobacterium avium ss. paratuberculosis Zoonosis - The Hundred Year War - Beyond Crohn's Disease.Frontiers in immunology · 2015Review
- Matrix metalloproteinases in inflammatory bowel disease: an update.Mediators of inflammation · 2015Review
- Unconventional animal models: a booster for new advances in host-pathogen interactions.Frontiers in cellular and infection microbiology · 2014Review
- Evaluation of a Mycobacterium avium subsp. paratuberculosis leuD mutant as a vaccine candidate against challenge in a caprine model.Clinical and vaccine immunology : CVI · 2013Article
- Article
- The study of gastric mucosa for possible bacterial causative agent of Crohn's disease.Iranian journal of medical sciences · 2012Article
- Detection of Bovine IgG Isotypes in a PPA-ELISA for Johne's Disease Diagnosis in Infected Herds.Veterinary medicine international · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The initial suggestion that Mycobacterium avium subsp. paratuberculosis (Map) might be involved in the pathogenesis of Crohn's disease (CD) was based on the apparent similarity of lesions in the intestine of patients with CD with those present in cattle infected with Map, the etiological agent of Johne's disease (JD). Recent investigations have now revealed the presence of Map or Map DNA in blood or lesions from adults and children with CD. Of special interest, Map has also been found in patients with other diseases as well as healthy subjects. The latter observations indicate all humans are susceptible to infection with Map and that, like with other mycobacterial pathogens such as Mycobacterium tuberculosis, infection does not invariably lead to development of clinical disease but rather development of a persistent latent stage of infection where an immune response controls but does not eliminate the pathogen. Limited information has been obtained on the immune response to Map in healthy subjects and patients with CD. Understanding how Map may be involved in the pathogenesis of CD will require a better understanding of the immune response to Map in one of its common hosts as well as healthy humans and patients with CD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.