ArticleBMC immunology2011
B lymphocyte intestinal homing in inflammatory bowel disease.
Article in BMC immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Microscopic enteritis: Bucharest consensus.World journal of gastroenterology · 2015Guideline
- Uncovering Immune Niches in Health and Disease Using Spatial Transcriptomics.European journal of immunology · 2026Review
- Regional and Sex-Dependent Immune Profiling Across the Colon in A Mouse Model of Ulcerative Colitis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Mucosal B Cell Expansion and Maturation Contribute to Colitis Pathogenesis.Inflammatory bowel diseases · 2026Article
- Generation and Phenotypic Analysis of the IL-10RAR104W/R104W Mouse Model.Inflammatory bowel diseases · 2025Article
- CD27Frontiers in immunology · 2021Article
- B cell regulation of the anti-tumor response and role in carcinogenesis.Journal for immunotherapy of cancer · 2016Review
- Gut-lung crosstalk in pulmonary involvement with inflammatory bowel diseases.World journal of gastroenterology · 2013Review
- Chicken innate immune response to oral infection with Salmonella enterica serovar Enteritidis.Veterinary research · 2013Article
- Morphological distribution of μ chains and cd15 receptors in colorectal polyp and adenocarcinoma specimens.BMC clinical pathology · 2013Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInflammatory bowel disease (IBD) is thought to be due to an abnormal interaction between the host immune system and commensal microflora. Within the intestinal immune system, B cells produce physiologically natural antibodies but pathologically atypical anti-neutrophil antibodies (xANCAs) are frequently observed in patients with IBD. The objective is to investigate the localisation of immunoglobulin-producing cells (IPCs) in samples of inflamed intestinal tissue taken from patients with IBD, and their possible relationship with clinical features.
methodsThe IPCs in small intestinal, colonic and rectal biopsy specimens of patients with IBD were analysed by means of immunofluorescence using polyclonal rabbit anti-human Ig and goat anti-human IgM. The B cell phenotype of the IPC-positive samples was assessed using monoclonal antibodies specific for CD79, CD20, CD23, CD21, CD5, λ and κ chains. Statistical correlations were sought between the histological findings and clinical expression.
resultsThe study involved 96 patients (64 with ulcerative colitis and 32 with Crohn's disease). Two different patterns of B lymphocyte infiltrates were found in the intestinal tissue: one was characterised by a strong to moderate stromal localisation of small IgM+/CD79+/CD20-/CD21-/CD23-/CD5± IPCs (42.7% of cases); in the other (57.3%) no such small IPCs were detected in stromal or epithelial tissues. IPCs were significantly less frequent in the patients with Crohn's disease than in those with ulcerative colitis (p = 0.004).
conclusionOur findings suggest that different immunopathogenetic pathways underlie chronic intestinal inflammation with different clinical expressions. The presence of small B lymphocytes resembling B-1 cells also seemed to be negatively associated with Crohn's disease. It can therefore be inferred that the gut contains an alternative population of B cells that have a regulatory function.
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