ArticleBiophysical journal2011
Nucleation and decay initiation are the stiffness-sensitive phases of focal adhesion maturation.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Integrins in Cardiovascular Health and Disease: Molecular Mechanisms and Therapeutic Opportunities.Biomolecules · 2025Review
- From stress fiber to focal adhesion: a role of actin crosslinkers in force transmission.Frontiers in cell and developmental biology · 2024Review
- Force-dependent focal adhesion assembly and disassembly: A computational study.PLoS computational biology · 2023Article
- Multiscale models of integrins and cellular adhesions.Current opinion in structural biology · 2023Review
- On modeling the multiscale mechanobiology of soft tissues: Challenges and progress.Biophysics reviews · 2022Review
- Multiscale mechanobiology: Coupling models of adhesion kinetics and nonlinear tissue mechanics.Biophysical journal · 2022Article
- The interplay between physical cues and mechanosensitive ion channels in cancer metastasis.Frontiers in cell and developmental biology · 2022Review
- Viscoelasticity Acts as a Marker for Tumor Extracellular Matrix Characteristics.Frontiers in cell and developmental biology · 2021Review
- Switching behaviour in vascular smooth muscle cell-matrix adhesion during oscillatory loading.Journal of theoretical biology · 2020Article
- Nanoscale integrin cluster dynamics controls cellular mechanosensing via FAKY397 phosphorylation.Science advances · 2020Article
- The bioenergetics of integrin-based adhesion, from single molecule dynamics to stability of macromolecular complexes.Computational and structural biotechnology journal · 2020Review
- Mechanosensitivity Occurs along the Adhesome's Force Train and Affects Traction Stress.Biophysical journal · 2019Article
- Dynamics of Mechanosensitive Nascent Adhesion Formation.Biophysical journal · 2019Article
- Effect of Loading History on Airway Smooth Muscle Cell-Matrix Adhesions.Biophysical journal · 2018Article
- Matching material and cellular timescales maximizes cell spreading on viscoelastic substrates.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Cell-Extracellular Matrix Mechanobiology: Forceful Tools and Emerging Needs for Basic and Translational Research.Nano letters · 2018Article
- Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology.Nature communications · 2017Article
- Cellular mechanosensing of the biophysical microenvironment: A review of mathematical models of biophysical regulation of cell responses.Physics of life reviews · 2017Review
- Mechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly.Nature communications · 2017Article
- Center or periphery? Modeling the effects of focal adhesion placement during cell spreading.PloS one · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
A cell plated on a two-dimensional substrate forms adhesions with that surface. These adhesions, which consist of aggregates of various proteins, are thought to be important in mechanosensation, the process by which the cell senses and responds to the mechanical properties of the substrate (e.g., stiffness). On the basis of experimental measurements, we model these proteins as idealized molecules that can bind to the substrate in a strain-dependent manner and can undergo a force-dependent state transition. The model forms molecular aggregates that are similar to adhesions. Substrate stiffness affects whether a simulated adhesion is initially formed and how long it grows, but not how that adhesion grows or shrinks. Our own experimental tests support these predictions, suggesting that the mechanosensitivity of adhesions is an emergent property of a simple molecular-mechanical system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.