ArticleBiophysical journal2011
Regulation of cell adhesion strength by peripheral focal adhesion distribution.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Spatial relationships between vinculin tension and actin at cell adhesions define cell colony positioning and identity.Biophysical journal · 2026Article
- Biophysical Considerations in Cell Fusion.Advances in experimental medicine and biology · 2026Review
- Effects of Topography and Extracellular Matrix Composition on Focal Adhesion Patterning in Human Corneal Fibroblasts.International journal of molecular sciences · 2025Article
- Hydrogel Viscoelasticity Modulates Cell Nascent Extracellular Matrix Deposition.Macromolecular rapid communications · 2025Article
- Modular molecular design of polymerized pro-estrogen materials enables controlled astrocyte response.Journal of materials chemistry. B · 2025Article
- Cell Adhesion and Local Cytokine Control on Protein-Functionalized PNIPAM-co-AAc Hydrogel Microcarriers.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Allosteric activation of vinculin by talin.Nature communications · 2023Article
- Article
- Mechanoimmunology: Are inflammatory epigenetic states of macrophages tuned by biophysical factors?APL bioengineering · 2022Review
- A switchable light-responsive azopolymer conjugating protein micropatterns with topography for mechanobiological studies.Frontiers in bioengineering and biotechnology · 2022Article
- An ultrafast enzyme-free acoustic technique for detaching adhered cells in microchannels.RSC advances · 2021Article
- Collagen production and niche engineering: A novel strategy for cancer cells to survive acidosis in DCIS and evolve.Evolutionary applications · 2020Article
- Elevated BMP and Mechanical Signaling Through YAP1/RhoA Poises FOP Mesenchymal Progenitors for Osteogenesis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Article
- Differential detachment of intact and viable cells of different sizes using laser-induced microbubbles.Biomedical optics express · 2019Article
- Probing Endothelial Cell Mechanics Through Connexin 43 Disruption.Experimental mechanics · 2019Article
- ADAM12 induction by Twist1 promotes tumor invasion and metastasis via regulation of invadopodia and focal adhesions.Journal of cell science · 2017Article
- Multiscale model predicts increasing focal adhesion size with decreasing stiffness in fibrous matrices.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Center or periphery? Modeling the effects of focal adhesion placement during cell spreading.PloS one · 2017Article
- Dissecting Collective Cell Behavior in Polarization and Alignment on Micropatterned Substrates.Biophysical journal · 2015Article
- Estrogens induce rapid cytoskeleton re-organization in human dermal fibroblasts via the non-classical receptor GPR30.PloS one · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell adhesion to extracellular matrices is a tightly regulated process that involves the complex interplay between biochemical and mechanical events at the cell-adhesive interface. Previous work established the spatiotemporal contributions of adhesive components to adhesion strength and identified a nonlinear dependence on cell spreading. This study was designed to investigate the regulation of cell-adhesion strength by the size and position of focal adhesions (FA). The cell-adhesive interface was engineered to direct FA assembly to the periphery of the cell-spreading area to delineate the cell-adhesive area from the cell-spreading area. It was observed that redistributing the same adhesive area over a larger cell-spreading area significantly enhanced cell-adhesion strength, but only up to a threshold area. Moreover, the size of the peripheral FAs, which was interpreted as an adhesive patch, did not directly govern the adhesion strength. Interestingly, this is in contrast to the previously reported functional role of FAs in regulating cellular traction where sizes of the peripheral FAs play a critical role. These findings demonstrate, to our knowledge for the first time, that two spatial regimes in cell-spreading area exist that uniquely govern the structure-function role of FAs in regulating cell-adhesion strength.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.