ArticleTranslational stroke research2011
Syndromics: a bioinformatics approach for neurotrauma research.
Article in Translational stroke research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sleep-disordered breathing is associated with brain vascular reactivity in spinal cord injury.Neurology · 2019Pooled it
- Assessment of dynamic stability and identification of key tasks, inertial sensors, and parameters in patients with bilateral and unilateral vestibulopathy: investigation in a semi-standardized environment.Journal of neuroengineering and rehabilitation · 2026Article
- Epigenomic Interactions Between Chronic Pain and Recurrent Pressure Injuries After Spinal Cord Injury.Epigenomes · 2025Article
- Prospective Harmonization, Common Data Elements, and Sharing Strategies for Multicenter Pre-Clinical Traumatic Brain Injury Research in the Translational Outcomes Project in Neurotrauma Consortium.Journal of neurotrauma · 2025Article
- Disuse plasticity limits spinal cord injury recovery.iScience · 2025Article
- An infrastructure for qualified data sharing and team science in late-stage translational spinal cord injury research.Experimental neurology · 2025Review
- Reflections on Data Sharing Practices in Spinal Cord Injury Research.Neuroinformatics · 2022Article
- Excavating FAIR Data: the Case of the Multicenter Animal Spinal Cord Injury Study (MASCIS), Blood Pressure, and Neuro-Recovery.Neuroinformatics · 2022Article
- Data-driven approach to integrating genomic and behavioral preclinical traumatic brain injury research.Frontiers in bioengineering and biotechnology · 2022Article
- Acute post-injury blockade of α2δ-1 calcium channel subunits prevents pathological autonomic plasticity after spinal cord injury.Cell reports · 2021Article
- Reproducible analysis of disease space via principal components using the novel R package syndRomics.eLife · 2021Article
- Data Dissemination: Shortening the Long Tail of Traumatic Brain Injury Dark Data.Journal of neurotrauma · 2020Review
- Exploration of surgical blood pressure management and expected motor recovery in individuals with traumatic spinal cord injury.Spinal cord · 2020Article
- Article
- Differential fracture response to traumatic brain injury suggests dominance of neuroinflammatory response in polytrauma.Scientific reports · 2019Article
- Testing a Multivariate Proteomic Panel for Traumatic Brain Injury Biomarker Discovery: A TRACK-TBI Pilot Study.Journal of neurotrauma · 2019Article
- Developing a data sharing community for spinal cord injury research.Experimental neurology · 2017Review
- Pulmonary outcomes following specialized respiratory management for acute cervical spinal cord injury: a retrospective analysis.Spinal cord · 2017Article
- What Is Being Trained? How Divergent Forms of Plasticity Compete To Shape Locomotor Recovery after Spinal Cord Injury.Journal of neurotrauma · 2017Review
- A data-driven approach for evaluating multi-modal therapy in traumatic brain injury.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Substantial scientific progress has been made in the past 50 years in delineating many of the biological mechanisms involved in the primary and secondary injuries following trauma to the spinal cord and brain. These advances have highlighted numerous potential therapeutic approaches that may help restore function after injury. Despite these advances, bench-to-bedside translation has remained elusive. Translational testing of novel therapies requires standardized measures of function for comparison across different laboratories, paradigms, and species. Although numerous functional assessments have been developed in animal models, it remains unclear how to best integrate this information to describe the complete translational "syndrome" produced by neurotrauma. The present paper describes a multivariate statistical framework for integrating diverse neurotrauma data and reviews the few papers to date that have taken an information-intensive approach for basic neurotrauma research. We argue that these papers can be described as the seminal works of a new field that we call "syndromics", which aim to apply informatics tools to disease models to characterize the full set of mechanistic inter-relationships from multi-scale data. In the future, centralized databases of raw neurotrauma data will enable better syndromic approaches and aid future translational research, leading to more efficient testing regimens and more clinically relevant findings.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.