ArticleArchives of osteoporosis2011
Bone pain and extremely low bone mineral density due to severe vitamin D deficiency in celiac disease.
Article in Archives of osteoporosis, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Menstrual Blood as a Non-Invasive Alternative for Monitoring Vitamin Levels.Journal of clinical medicine · 2024Article
- Superscan Pattern on Bone Scintigraphy: A Comprehensive Review.Diagnostics (Basel, Switzerland) · 2024Review
- Vitamin D Sources, Metabolism, and Deficiency: Available Compounds and Guidelines for Its Treatment.Metabolites · 2021Review
- Review
- Osteomalacia and Vitamin D Status: A Clinical Update 2020.JBMR plus · 2021Article
- Assessment of fractal dimension and panoramic radiomorphometric indices in women with celiac disease.Oral radiology · 2020Article
- Association of serum 25-hydroxyvitamin D status with bone mineral density in 0-7 year old children.Oncotarget · 2016Article
- Proximal muscle weakness as a result of osteomalacia associated with celiac disease: a case report.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- Mathematical model for bone mineralization.Frontiers in cell and developmental biology · 2015Article
- Severe rickets in a young girl caused by celiac disease: the tragedy of delayed diagnosis: a case report.BMC research notes · 2014Article
- Bone densitometry in patients with osteomalacia: is it valuable?Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases · 2013Review
- Induction of osteoporosis with its influence on osteoporotic determinants and their interrelationships in rats by DEXA.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
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5 authors.
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Abstract
case reportA 29-year-old wheelchair-bound woman was presented to us by the gastroenterologist with suspected osteomalacia. She had lived in the Netherlands all her life and was born of Moroccan parents. Her medical history revealed iron deficiency, growth retardation, and celiac disease, for which she was put on a gluten-free diet. She had progressive bone pain since 2 years, difficulty with walking, and about 15 kg weight loss. She had a short stature, scoliosis, and pronounced kyphosis of the spine and poor condition of her teeth. Laboratory results showed hypocalcemia, an immeasurable serum 25-hydroxyvitamin D level, and elevated parathyroid hormone and alkaline phosphatase levels. Spinal radiographs showed unsharp, low contrast vertebrae. Bone mineral density measurement at the lumbar spine and hip showed a T-score of -6.0 and -6.5, respectively. A bone scintigraphy showed multiple hotspots in ribs, sternum, mandible, and long bones. A duodenal biopsy revealed villous atrophy (Marsh 3C) and positive antibodies against endomysium, transglutaminase, and gliadin, compatible with active celiac disease. A bone biopsy showed severe osteomalacia but normal bone volume. She was treated with calcium intravenously and later orally. Furthermore, she was treated with high oral doses of vitamin D and a gluten-free diet. After a few weeks of treatment, her bone pain decreased, and her muscle strength improved. DISCUSSION: In this article, the pathophysiology and occurrence of osteomalacia as a complication of celiac disease are discussed. Low bone mineral density can point to osteomalacia as well as osteoporosis.
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