ArticleFrontiers in neurology2011
Compensation following bilateral vestibular damage.
Article in Frontiers in neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Vestibular implant: does it really work? A systematic review.Brazilian journal of otorhinolaryngologyPooled it
- Concurrent vestibular activation and postural training recalibrate somatosensory, vestibular and gaze stabilization processes.PloS one · 2024Trial
- Prospective cohort study on the predictors of fall risk in 119 patients with bilateral vestibulopathy.PloS one · 2020Trial
- Clinical-functional dissociation in bilateral vestibulopathy: determinants of disability beyond peripheral vestibular loss.Journal of neurology · 2026Article
- Bilateral vestibulopathy - insight in impact on quality of life and economic burden.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Perceptual response characterization in acute vestibular implant stimulation.Journal of neurology · 2025Article
- Pediatric Bilateral Vestibular Hypofunction: A Review of 26 Cases.The Laryngoscope · 2025Article
- Clinical Research on Positron Emission Tomography Imaging of the Neuro-Stimulation System in Patients with Cochleo-Vestibular Implants: Is There a Response Beyond the Peripheral Organ?Journal of clinical medicine · 2025Article
- Mechanisms underlying treatment effects of vestibular noise stimulation on postural instability in patients with bilateral vestibulopathy.Journal of neurology · 2024Article
- Augmented ocular vestibular-evoked myogenic potentials in postural orthostatic tachycardia syndrome.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Article
- Compensatory cognition in neurological diseases and aging: A review of animal and human studies.Aging brain · 2023Review
- Vestibular prosthesis: from basic research to clinics.Frontiers in integrative neuroscience · 2023Review
- Utricular dysfunction in patients with orthostatic hypotension.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- Longitudinal [Scientific reports · 2022Article
- Lesion-induced changes of brevican expression in the perineuronal net of the superior vestibular nucleus.Neural regeneration research · 2022Article
- The otolith vermis: A systems neuroscience theory of the Nodulus and Uvula.Frontiers in systems neuroscience · 2022Article
- Effect of Oral Allylnitrile Administration on Cochlear Functioning in Mice Following Comparison of Different Anesthetics for Hearing Assessment.Frontiers in toxicology · 2021Article
- Vestibular Function After Cochlear Implantation in Partial Deafness Treatment.Frontiers in neurology · 2021Article
- Bilateral vestibulopathy: beyond imbalance and oscillopsia.Journal of neurology · 2020Article
- Visual deprivation independent shift of ocular dominance induced by cross-modal plasticity.PloS one · 2019Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Bilateral loss of vestibular inputs affects far fewer patients than unilateral inner ear damage, and thus has been understudied. In both animal subjects and human patients, bilateral vestibular hypofunction (BVH) produces a variety of clinical problems, including impaired balance control, inability to maintain stable blood pressure during postural changes, difficulty in visual targeting of images, and disturbances in spatial memory and navigational performance. Experiments in animals have shown that non-labyrinthine inputs to the vestibular nuclei are rapidly amplified following the onset of BVH, which may explain the recovery of postural stability and orthostatic tolerance that occurs within 10 days. However, the loss of the vestibulo-ocular reflex and degraded spatial cognition appear to be permanent in animals with BVH. Current concepts of the compensatory mechanisms in humans with BVH are largely inferential, as there is a lack of data from patients early in the disease process. Translation of animal studies of compensation for BVH into therapeutic strategies and subsequent application in the clinic is the most likely route to improve treatment. In addition to physical therapy, two types of prosthetic devices have been proposed to treat individuals with bilateral loss of vestibular inputs: those that provide tactile stimulation to indicate body position in space, and those that deliver electrical stimuli to branches of the vestibular nerve in accordance with head movements. The relative efficacy of these two treatment paradigms, and whether they can be combined to facilitate recovery, is yet to be ascertained.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.