ArticleFrontiers in neurology2011
The role of ATP in sleep regulation.
Article in Frontiers in neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- The role of sleep disorders in orchestrating proteomic dysfunction and multi-morbidity.Molecular psychiatry · 2026Review
- Adenosine ABiomolecules & therapeutics · 2026Review
- Advances in biomarkers for diagnosing and prognosticating disorders of consciousness.Frontiers in neuroscience · 2026Review
- Signals of energy availability in sleep: consequences of a fat-based metabolism.Frontiers in nutrition · 2024Review
- Using spectral continuity to extract breathing rate from heart rate and its applications in sleep physiology.Frontiers in physiology · 2024Article
- Sleep Promotion by 3-Hydroxy-4-Iminobutyric Acid in WalnutResearch (Washington, D.C.) · 2023Article
- The Relationship Between Thiamine Intake and Long Sleep Duration: Results From the Korea National Health and Nutrition Examination Survey.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2022Article
- The Effect of Sleep Deprivation and Subsequent Recovery Period on the Synaptic Proteome of Rat Cerebral Cortex.Molecular neurobiology · 2022Article
- Circadian Clocks, Sleep, and Metabolism.Advances in experimental medicine and biology · 2021Article
- Recent Progress in Lab-On-a-Chip Systems for the Monitoring of Metabolites for Mammalian and Microbial Cell Research.Sensors (Basel, Switzerland) · 2019Review
- HO-1 and CD39: It Takes Two to Protect the Realm.Frontiers in immunology · 2019Review
- Serum and Brain Metabolomic Variations Reveal Perturbation of Sleep Deprivation on Rats and Ameliorate Effect of Total Ginsenoside Treatment.International journal of genomics · 2017Article
- The ATP-Gated P2X7 Receptor As a Target for the Treatment of Drug-Resistant Epilepsy.Frontiers in neuroscience · 2017Review
- Sleep deprivation impairs memory by attenuating mTORC1-dependent protein synthesis.Science signaling · 2016Article
- Diffuse brain injury does not affect chronic sleep patterns in the mouse.Brain injury · 2014Article
- Diffuse brain injury induces acute post-traumatic sleep.PloS one · 2014Article
- Augmented generation of protein fragments during wakefulness as the molecular cause of sleep: a hypothesis.Protein science : a publication of the Protein Society · 2012Article
- Adenosine deaminase polymorphism affects sleep EEG spectral power in a large epidemiological sample.PloS one · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the functions of sleep is to maintain energy balance in the brain. There are a variety of hypotheses related to how metabolic pathways interact with sleep/wake regulation. A major finding that demonstrates an interaction between sleep and metabolic homeostasis is the involvement of adenosine in sleep homeostasis. An accumulation of adenosine is supplied from ATP, which can act as an energy currency in the cell. Extracellularly, ATP can act as an activity-dependent signaling molecule, especially in regard to communication between neurons and glia, including astrocytes. Furthermore, the intracellular AMP/ATP ratio controls the activity of AMP-activated protein kinase, which is a potent energy regulator and is recently reported to play a role in the regulation of sleep homeostasis. Brain ATP may support multiple functions in the regulation of the sleep/wake cycle and sleep homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.