ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2012
Status of proinflammatory and anti-inflammatory cytokines in different brain regions of a rat model of Japanese encephalitis.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- Antidepressant Activity of Agarwood Essential Oil: A Mechanistic Study on Inflammatory and Neuroprotective Signaling Pathways.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Leukocyte recruitment in flavivirus-induced encephalitis.Frontiers in immunology · 2025Review
- CCR2 Inhibition Reduces Neurotoxic Microglia Activation Phenotype After Japanese Encephalitis Viral Infection.Frontiers in cellular neuroscience · 2020Article
- Review of Emerging Japanese Encephalitis Virus: New Aspects and Concepts about Entry into the Brain and Inter-Cellular Spreading.Pathogens (Basel, Switzerland) · 2019Review
- In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus.Scientific reports · 2018Article
- Regulation of inflammation in Japanese encephalitis.Journal of neuroinflammation · 2017Review
- A Japanese encephalitis virus genotype 5 molecular clone is highly neuropathogenic in a mouse model: impact of the structural protein region on virulence.Journal of virology · 2015Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study evaluated cytokines and chemokine in different regions of the rat brain at different time points following Japanese encephalitis virus (JEV) infection.
designTwelve-day-old Wistar rats were infected by intracerebral inoculation of 3 × 10(6) plaque-forming units of JEV 78668A strain. Expression of cytokines and chemokine was assayed using cytokine bead array in different regions of the brain at 3, 6, 10 and 20 days post-inoculation (dpi). Pathological changes including immunohistochemistry for JEV antigen were observed.
resultsThe cytokine levels were increased in the acute stage and declined on follow-up. In the acute stage (6 dpi), the levels of TNF-α, IFN-γ, IL-6 and IL-10 were maximum in the cortex, whereas the level of IL-4 was maximum in the striatum. Lower levels of these cytokines were observed in mid-brain and thalamus compared to other regions studied. Maximum expression of JEV antigen and histopathological changes as well as cytokines and chemokine were observed at 6 dpi in all the brain regions studied, but declined thereafter.
conclusionThis experimental study revealed maximum expression of cytokines and chemokine at 6 dpi of JEV infection which corresponded with histopathological changes in different brain regions.
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