ArticleAJNR. American journal of neuroradiology2012
The impact of thromboemboli histology on the performance of a mechanical thrombectomy device.
Article in AJNR. American journal of neuroradiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.
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Who cites it
81 citing papers in PubMed, 1 synthesis or guideline pooled it, 163 citations in OpenAlex.
- Large animals in neurointerventional research: A systematic review on models, techniques and their application in endovascular procedures for stroke, aneurysms and vascular malformations.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Pooled it
- Susceptibility Vessel Sign and Intravenous Alteplase in Stroke Patients Treated with Thrombectomy : A Secondary Analysis of the SWIFT DIRECT Trial.Clinical neuroradiology · 2025Trial
- The Impact of Histological Clot Composition in Embolic Stroke.Clinical neuroradiology · 2016Trial
- Subacute Pulmonary Embolism: Insights from a National Registry of Catheter-Directed Interventions.Journal of clinical medicine · 2026Article
- Optimizing catheter centering enhances mechanical thrombectomy success: Performance difference in cases using novel macrowires versus traditional microwires.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026Article
- First clinical multicenter experience of the new NeVa NET 5.5 thrombectomy device.Journal of neurointerventional surgery · 2026Article
- Experimental Characterisation of Differently Composed Thrombus Entities with Spectral-Detector-CT.Neurology international · 2026Article
- Making the invisible visible: integrated visualization and automated quantification of thrombus deformation during mechanical thrombectomy.Frontiers in medical technology · 2026Article
- Does the susceptibility vessel sign influence the effectiveness of intravenous thrombolysis before endovascular thrombectomy in acute ischaemic stroke?European stroke journal · 2026Article
- Is There a Relationship Between the Histopathological Features and Anatomical Locations of Thrombi Obtained During Endovascular Thrombectomy in Acute Ischemic Stroke and Its Comorbid Diseases?Diagnostics (Basel, Switzerland) · 2025Article
- Targeting hypercoagulability in ischemic stroke modulates fibrin-driven microglial polarization via JAK-STAT pathway.Journal of neuroinflammation · 2025Article
- Programmable MRI contrast switching for spatiotemporal mapping of thrombus maturation via enzyme-directed nanoprobe reconfiguration.Nano convergence · 2025Article
- A novel method for preparing clot analogs under dynamic vortical flow for testing mechanical thrombectomy devices.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Self-Sensing with Hollow Cylindrical Transducers for Histotripsy-Enhanced Aspiration Mechanical Thrombectomy Applications.Sensors (Basel, Switzerland) · 2025Article
- Development of physiologically relevant synthetic thrombus for use in visual analysis of in vitro mechanical thrombectomy device testing.Journal of neurointerventional surgery · 2025Article
- Histological analysis of thrombus composition in acute ischemic stroke with large vessel occlusion: impact of r-tPA treatment.Frontiers in neuroscience · 2025Article
- Unraveling the Enigma: Correlating Thrombus Histopathology With the Number of Passes in Mechanical Thrombectomy.Cureus · 2025Article
- Preventing Embolization to a New Vascular Territory: An in Vitro Study Exploring Alternative Techniques for Dual-Stent-Retriever Cerebral Thrombectomy.Journal of neuroendovascular therapy · 2025Article
- Usefulness of Mechanical Thrombectomy in Patients with Cancer Who Developed Cerebral Infarction.Neurologia medico-chirurgica · 2024Article
- Optimizing stent retrievers for mechanical enhancement and in vitro testing in acute ischemic stroke models.Biomedical engineering online · 2024Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
background and purposeRecently we published a novel method of thrombus preparation for use in a swine model for evaluation of thrombectomy designs. The clot (fibrin rich clot) is characterized by its similarity in histologic characteristics to the thromboemboli recovered from stroke patients. The purpose of this latest study was to evaluate if the performance of a mechanical thrombectomy device was affected by the histologic characteristics of thromboembolus. Erythrocyte rich clot, which was created using exogenous thrombin, and the novel experimental clot with abundance of fibrin/cellular component were used for comparison. The Merci clot retriever was used for the evaluation and the angiographic outcomes were analyzed. MATERIALS AND
methodsTwo histologically different types of experimental clot, a conventionally used thrombin-induced clot (erythrocyte-rich clot) and a novel experimental clot that is similar in histologic characteristics to the thromboemboli recovered from patients with stroke (fibrin-rich clot), were prepared. Eight extracranial arteries in swine were occluded with erythrocyte-rich clot (group A), and 8 were occluded with fibrin-rich clot (group B), and MT by using the Merci clot retriever device was performed. Angiographic results in each group were evaluated.
resultsA total of 48 attempts at MT were made. The average number of attempts to achieve TIMI grade II or III recanalization was 2.75 times in group A and 4.5 times in group B (P < .001), respectively. The mean time to achieve recanalization was 15.5 minutes in group A and 81.5 minutes in group B (P < .01). Every vessel in group A showed recanalization (100%), whereas only 3 of 8 samples (37.5%) achieved recanalization in group B.
conclusionsIn this model, arteries occluded by fibrin-rich clot demonstrated a significantly lower recanalization rate, lower final TIMI score, and a longer mean recanalization time than did arteries occluded by erythrocyte-rich clot. The angiographic outcome of MT by using the Merci clot retriever system was influenced by the histologic characteristics of the occluding thromboembolus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.