ArticleMedical science monitor : international medical journal of experimental and clinical research2012
Reduced endothelial function in the skin in Southeast Asians compared to Caucasians.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- The effect of acute administration of vitamin D on micro vascular endothelial function in Caucasians and South Asian Indians.Medical science monitor : international medical journal of experimental and clinical research · 2013Trial
- CoQ10 and endothelial function in Asians from Korea compared to Asians born in the United States and US born Caucasians.Medical science monitor : international medical journal of experimental and clinical research · 2013Trial
- Protective effect of anti-oxidants on endothelial function in young Korean-Asians compared to Caucasians.Medical science monitor : international medical journal of experimental and clinical research · 2012Trial
- Differences in endothelial function between Korean-Asians and Caucasians.Medical science monitor : international medical journal of experimental and clinical research · 2012Trial
- Dermatology: how to manage rosacea in skin of colour.Drugs in context · 2022Review
- Comparison of Endothelial Function in Asian Indians Versus Caucasians.Metabolic syndrome and related disorders · 2016Article
- What is more damaging to vascular endothelial function: Diabetes, age, high BMI, or all of the above?Medical science monitor : international medical journal of experimental and clinical research · 2013Article
- Resting blood flow in the skin: does it exist, and what is the influence of temperature, aging, and diabetes?Journal of diabetes science and technology · 2012Review
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Authors and funding
18 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe reaction of vascular endothelial cells to occlusion and heat in Southeast Asian Indians (SAI) compared to Caucasians (C) has not been studied, although genetic differences are found in endothelial cells between the races. MATERIAL/
methodsTen C and Ten SAI (<35 years old) male and female subjects participated. There was no difference in the demographics of the subjects except that the SAI group had been in the United States for 6 months; C was natives to the US. Endothelial function was assessed by the response of the circulation (BF) to local heating and the response to vascular occlusion. The effects of local heat on circulation in the skin on the forearm was assessed by applying heat for 6 minutes at temperatures, 38, 40 and 42°C on 3 separate days. On different days, vascular occlusion was applied for 4 minutes to the same arm and skin blood flow was measured for 2 minutes after occlusion; skin temperature was either 31°C or 42°C.
resultsWhen occlusion was applied at a skin temperature of 31°C, the BF response to occlusion was significantly lower in the SAI cohort compared to C (peak BF C = 617 ± 88.2 flux, SAE = 284 ± 73 flux). The same effect was seen at skin temperatures of 42°C. The circulatory response to heat was also significantly less in SAI compared to C at each temperature examined (p<0.05)(for temperatures of 38, 40 and 42°C, peak blood flow for C was 374.7 ± 81.2, 551.9 ± 91.3 and 725.9 ± 107 flux respectively and 248.5 ± 86.2, 361.4 ± 104.3 and 455.3 ± 109.7 flux respectively for SAI. (p<0.05).
conclusionsThus there seems to be big differences in these 2 populations in endothelial response to these stressors. The difference may be due to genetic variations between the 2 groups of subjects.
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