ArticleBiological psychiatry2012
Neural activation during facial emotion processing in unmedicated bipolar depression, euthymia, and mania.
Article in Biological psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Facial emotion recognition deficits in bipolar disorder: A systematic review and meta-analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2026Pooled it
- Common and distinct patterns of intrinsic brain activity alterations in major depression and bipolar disorder: voxel-based meta-analysis.Translational psychiatry · 2020Pooled it
- Large-scale network dysfunction in the acute state compared to the remitted state of bipolar disorder: A meta-analysis of resting-state functional connectivity.EBioMedicine · 2020Pooled it
- Developmental meta-analyses of the functional neural correlates of bipolar disorder.JAMA psychiatry · 2014Pooled it
- fMRI brain activation changes following treatment of a first bipolar manic episode.Bipolar disorders · 2016Trial
- Anxiety Suppressed Prefrontal Cortex Brain Activity: Insights From a Large Sample of Functional Near-Infrared Spectroscopy (fNIRS) Data.Depression and anxiety · 2026Article
- Reconceptualizing bipolar disorder through an integrative biological lens: synthesis, convergence, and emerging directions.Frontiers in integrative neuroscience · 2026Review
- Advances in functional MRI research in bipolar disorder: from the perspective of mood states.General psychiatry · 2024Review
- Psychotic Symptom, Mood, and Cognition-associated Multimodal MRI Reveal Shared Links to the Salience Network Within the Psychosis Spectrum Disorders.Schizophrenia bulletin · 2023Article
- Testing the effect of high-definition transcranial direct current stimulation of the insular cortex to modulate decision-making and executive control.Frontiers in behavioral neuroscience · 2023Article
- Euthymic patients with predominantly manic polarity avoid happy faces in a dot probe task.International journal of bipolar disorders · 2022Article
- A graph theory-based whole brain approach to assess mood state differences in adolescents and young adults with bipolar disorder.Bipolar disorders · 2022Article
- Associations between cannabis use, cannabis use disorder, and mood disorders: longitudinal, genetic, and neurocognitive evidence.Psychopharmacology · 2022Review
- The Impact of Lithium on Brain Function in Bipolar Disorder: An Updated Review of Functional Magnetic Resonance Imaging Studies.CNS drugs · 2021Review
- Variation in rostral anterior cingulate functional connectivity with amygdala and caudate during first manic episode distinguish bipolar young adults who do not remit following treatment.Bipolar disorders · 2021Article
- Resting-state functional connectivity of neural circuits associated with primary and secondary rewards in patients with bipolar disorder.Social cognitive and affective neuroscience · 2020Article
- Inefficient Involvement of Insula in Sensorineural Hearing Loss.Frontiers in neuroscience · 2019Article
- Age-specific effects of structural and functional connectivity in prefrontal-amygdala circuitry in women with bipolar disorder.BMC psychiatry · 2018Article
- The Insula: An Underestimated Brain Area in Clinical Neuroscience, Psychiatry, and Neurology.Trends in neurosciences · 2017Review
- Decreased empathy response to other people's pain in bipolar disorder: evidence from an event-related potential study.Scientific reports · 2017Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundStudies incorporating direct comparisons across all phases of bipolar (BP) disorder are needed to elucidate the pathophysiology of bipolar disorder. However, functional neuroimaging studies that differentiate bipolar mood states from each other and from healthy subjects are few and have yielded inconsistent findings.
methodsOne hundred five unmedicated adults were recruited: 30 with current bipolar depression (BPD), 30 with current bipolar hypomania or mania (BPM), 15 bipolar euthymic (BPE), and 30 healthy control subjects (HC). All subjects were diagnosed with DSM-IV BP (type I or II) using a structured clinical interview. Groups were age- and gender-ratio matched. In 3T functional magnetic resonance imaging experiments, subjects completed a negative facial emotion matching task.
resultsBipolar euthymic and BPD groups exhibited increased amygdala activation compared with HCs in response to the negative faces; however, in the BPM group, this increase was not seen. Conversely, both BPE and BPM groups had increased activation in the insula relative to HCs, but in the BPD group, this effect was not seen. All three BP groups exhibited increased activation of the putamen compared with HCs. In the cortical areas, the BPM group exhibited decreased left lateral orbitofrontal cortex activation compared with both BPEs and HCs, increased dorsal anterior cingulate cortex activation compared with the BPD group, and increased dorsolateral prefrontal cortical activation compared with all other groups.
conclusionsBoth state- and trait-related abnormalities in corticolimbic activation were seen in response to the negative facial emotion processing in a large sample of unmedicated adults across BP mood states.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.