ReviewToxicology and applied pharmacology2012
Elucidating the mechanisms of nickel compound uptake: a review of particulate and nano-nickel endocytosis and toxicity.
Review in Toxicology and applied pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Relationships Between Biological Heavy Metals and Breast Cancer: A Systematic Review and Meta-Analysis.Frontiers in nutrition · 2022Pooled it
- Cellular Uptake, Intracellular Fate, and Cytotoxicity of Micro- and Nanoparticulate Nickel Substances in Human Lung Cells.Chemical research in toxicology · 2026Article
- Unravelling Mechanisms of Oxinflammation Induced by Heavy Metals.Metabolites · 2026Review
- Altered trace and toxic element profiles in breast tissue: a case-control study of cancer risk.Scientific reports · 2026Article
- Metal carcinogens and cancer: integrating genetic and epigenetic perspectives.Frontiers in oncology · 2026Review
- Metal Ion Signaling in Biomedicine.Chemical reviews · 2025Review
- Leveraging Microneedles for Raised Scar Management.Polymers · 2025Review
- Heavy Metal Exposure-induced Cardiovascular Diseases: Molecular Mechanisms and Therapeutic Role of Antioxidants.Current medicinal chemistry · 2025Review
- Speciation of Potentially Carcinogenic Trace Nickel(II) Ion Levels in Human Saliva: A Sequential Metabolomics-Facilitated High-FieldMetabolites · 2024Article
- Harnessing Novel Reduced Graphene Oxide-Based Aerogel for Efficient Organic Contaminant and Heavy Metal Removal in Aqueous Environments.Nanomaterials (Basel, Switzerland) · 2024Article
- Protective effect of resveratrol on nickel-refining fumes-induced inflammatory damage.Cell biochemistry and biophysics · 2024Article
- Additively Manufactured 17-4 PH Stainless Steels for Fracture Management Devices.Virtual and physical prototyping · 2024Article
- Nickel Nanoparticles Induced Hepatotoxicity in Mice via Lipid-Metabolism-Dysfunction-Regulated Inflammatory Injury.Molecules (Basel, Switzerland) · 2023Article
- Risk Characterization of the Armenian Population to Nickel: Application of Deterministic and Probabilistic Approaches to a Total Diet Study in Yerevan City.Biological trace element research · 2023Article
- Specific Six-Transmembrane Epithelial Antigen of the Prostate 1 Capture with Gellan Gum Microspheres: Design, Optimization and Integration.International journal of molecular sciences · 2023Article
- Editorial: The mechanism of trace elements on regulating immunity in prevention and control of human and animal diseases.Frontiers in immunology · 2023Article
- Mechanistic considerations and biomarkers level in nickel-induced neurodegenerative diseases: An updated systematic review.IBRO neuroscience reports · 2022Review
- Peroral Toxicological Assessment of Two-Dimensional Forms of Nickel Nanoparticles Sized between 20 and 120 nm.Nanomaterials (Basel, Switzerland) · 2022Article
- Ni(II) Ions May Target the Entire Melatonin Biosynthesis Pathway-A Plausible Mechanism of Nickel Toxicity.Molecules (Basel, Switzerland) · 2022Article
- A comprehensive review on the sources, essentiality and toxicological profile of nickel.RSC advances · 2022Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Nickel (Ni) is a worldwide pollutant and contaminant that humans are exposed to through various avenues resulting in multiple toxic responses - most alarming is its clear carcinogenic nature. A variety of particulate Ni compounds persist in the environment and can be distinguished by characteristics such as solubility, structure, and surface charge. These characteristics influence cellular uptake and toxicity. Some particulate forms of Ni are carcinogenic and are directly and rapidly endocytized by cells. A series of studies conducted in the 1980s observed this process, and we have reanalyzed the results of these studies to help elucidate the molecular mechanism of particulate Ni uptake. Originally the process of uptake observed was described as phagocytosis, however in the context of recent research we hypothesize that the process is macropinocytosis and/or clathrin mediated endocytosis. Primary considerations in determining the route of uptake here include calcium dependence, particle size, and inhibition through temperature and pharmacological approaches. Particle characteristics that influenced uptake include size, charge, surface characteristics, and structure. This discussion is relevant in the context of nanoparticle studies and the emerging interest in nano-nickel (nano-Ni), where toxicity assessments require a clear understanding of the parameters of particulate uptake and where establishment of such parameters is often obscured through inconsistencies across experimental systems. In this regard, this review aims to carefully document one system (particulate nickel compound uptake) and characterize its properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.