ArticleJournal of inflammation (London, England)2011
Ageing prolongs inflammatory marker expression in regenerating rat skeletal muscles after injury.
Article in Journal of inflammation (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Review
- Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration.Sports medicine and health science · 2022Article
- Investigating the Potential for Sulforaphane to Attenuate Gastrointestinal Dysfunction inNutrients · 2021Article
- Aging of the immune system and impaired muscle regeneration: A failure of immunomodulation of adult myogenesis.Experimental gerontology · 2021Review
- Inflamma-miR-21 Negatively Regulates Myogenesis during Ageing.Antioxidants (Basel, Switzerland) · 2020Article
- Relationship of Peripheral Lymphocyte Subsets and Skeletal Muscle Mass Index in Sarcopenia: A Cross-Sectional Study.The journal of nutrition, health & aging · 2020Article
- Macrophage Regulation of Muscle Regrowth From Disuse in Aging.Exercise and sport sciences reviews · 2019Review
- Deletion of suppressor of cytokine signaling 3 (SOCS3) in muscle stem cells does not alter muscle regeneration in mice after injury.PloS one · 2019Article
- Myeloid Cell Responses to Contraction-induced Injury Differ in Muscles of Young and Old Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- CXCL10 increases in human skeletal muscle following damage but is not necessary for muscle regeneration.Physiological reports · 2018Article
- The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates.Frontiers in medicine · 2018Review
- The NLRP3 inflammasome contributes to sarcopenia and lower muscle glycolytic potential in old mice.American journal of physiology. Endocrinology and metabolism · 2017Article
- Absence of CCR2 results in an inflammaging environment in young mice with age-independent impairments in muscle regeneration.Journal of leukocyte biology · 2016Article
- Differential effects of leucine supplementation in young and aged mice at the onset of skeletal muscle regeneration.Mechanisms of ageing and development · 2016Article
- Article
- Muscle-specific deletion of SOCS3 increases the early inflammatory response but does not affect regeneration after myotoxic injury.Skeletal muscle · 2016Article
- Effect of laser therapy on skeletal muscle repair process in diabetic rats.Lasers in medical science · 2013Article
- Short-term bed rest increases TLR4 and IL-6 expression in skeletal muscle of older adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Effect of photobiomodulation on expression of IL-1β in skeletal muscle following acute injury.Lasers in medical science · 2013Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSome of the most serious consequences of normal ageing relate to its effects on skeletal muscle, particularly significant wasting and associated weakness, termed "sarcopenia". The underlying mechanisms of sarcopenia have yet to be elucidated completely but an altered muscle inflammatory response after injury is a likely contributing factor. In this study we investigated age-related changes in the expression of numerous inflammatory markers linked to successful muscle regeneration.
methodsRight extensor digitorum longus (EDL) muscles from young (3 month), adult (12 month) and old (24 month) male F344 rats were injected with bupivacaine hydrochloride to cause complete muscle fibre degeneration, then excised 12, 24, 36, and 72 hours later (n = 5/age group/time point). We used qRT-PCR to quantify the mRNA expression levels of the inflammatory markers TNFα, IFNγ, IL1, IL18, IL6, and CD18 as well as regenerative markers MyoD and myogenin.
resultsInflammatory markers were all increased significantly in all age groups after myotoxic injury. There was a trend for expression of inflammatory markers to be higher in uninjured muscles of old rats, especially at 72 hours post injury where the expression levels of several markers was significantly higher in old compared with young and adult rats. There was also a decrease in the expression of regenerative markers in old rats at 72 hours post injury.
conclusionOur findings identify a prolonged inflammatory signature in injured muscles from old compared with young and adult rats together with a blunted expression of key markers of regeneration in muscles of old rats. Importantly, our findings identify potential targets for future therapeutic strategies for improving the regenerative capacity of skeletal muscle during ageing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.