ArticleJournal of biomechanical engineering2011
Tortuosity triggers platelet activation and thrombus formation in microvessels.
Article in Journal of biomechanical engineering, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- Revisiting the tension-free paradigm: Axially prestretched elastomeric nanofibrillar grafts restore artery-like axial biomechanics in a preclinical model.Acta biomaterialia · 2026Article
- Retinal Vessel Traits and the Risk of Stroke: The Canadian Longitudinal Study on Aging.Ophthalmology science · 2026Article
- Improving the 3D Printability of Sugar Glass to Engineer Sacrificial Vascular Templates.3D printing and additive manufacturing · 2023Article
- Models of Shear-Induced Platelet Activation and Numerical Implementation With Computational Fluid Dynamics Approaches.Journal of biomechanical engineering · 2022Article
- Age-Related Tortuosity of Carotid and Vertebral Arteries: Quantitative Evaluation With MR Angiography.Frontiers in neurology · 2022Article
- Retinal arteriolar tortuosity and fractal dimension are associated with long-term cardiovascular outcomes in people with type 2 diabetes.Diabetologia · 2021Article
- Method for the simulation of blood platelet shape and its evolution during activation.PLoS computational biology · 2018Article
- Fluid-structure interaction modeling of aneurysmal arteries under steady-state and pulsatile blood flow: a stability analysis.Computer methods in biomechanics and biomedical engineering · 2018Article
- Age-related Impairment of Vascular Structure and Functions.Aging and disease · 2017Review
- Arterial wall remodeling under sustained axial twisting in rats.Journal of biomechanics · 2017Article
- Twist buckling of veins under torsional loading.Journal of biomechanics · 2017Article
- Numerical Simulation of Thrombotic Occlusion in Tortuous Arterioles.Journal of cardiology and cardiovascular medicine · 2017Article
- Coagulation Factor XI Promotes Distal Platelet Activation and Single Platelet Consumption in the Bloodstream Under Shear Flow.Arteriosclerosis, thrombosis, and vascular biology · 2016Article
- Computational simulation of platelet interactions in the initiation of stent thrombosis due to stent malapposition.Physical biology · 2016Article
- Article
- Murine Kidney Transplant Technique.Journal of visualized experiments : JoVE · 2015Article
- Partial eNOS deficiency causes spontaneous thrombotic cerebral infarction, amyloid angiopathy and cognitive impairment.Molecular neurodegeneration · 2015Article
- Stability of carotid artery under steady-state and pulsatile blood flow: a fluid-structure interaction study.Journal of biomechanical engineering · 2015Article
- Simulation of the microscopic process during initiation of stent thrombosis.Computers in biology and medicine · 2015Article
- Mechanical instability of normal and aneurysmal arteries.Journal of biomechanics · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Tortuous blood vessels are often seen in humans in association with thrombosis, atherosclerosis, hypertension, and aging. Vessel tortuosity can cause high fluid shear stress, likely promoting thrombosis. However, the underlying physical mechanisms and microscale processes are poorly understood. Accordingly, the objectives of this study were to develop and use a new computational approach to determine the effects of venule tortuosity and fluid velocity on thrombus initiation. The transport, collision, shear-induced activation, and receptor-ligand adhesion of individual platelets in thrombus formation were simulated using discrete element method. The shear-induced activation model assumed that a platelet became activated if it experienced a shear stress above a relative critical shear stress or if it contacted an activated platelet. Venules of various levels of tortuosity were simulated for a mean flow velocity of 0.10 cm s(-1), and a tortuous arteriole was simulated for a mean velocity of 0.47 cm s(-1). Our results showed that thrombus was initiated at inner walls in curved regions due to platelet activation in agreement with experimental studies. Increased venule tortuosity modified fluid flow to hasten thrombus initiation. Compared to the same sized venule, flow in the arteriole generated a higher amount of mural thrombi and platelet activation rate. The results suggest that the extent of tortuosity is an important factor in thrombus initiation in microvessels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.