Evidence map›Paper›PMID 22206271›Full record

Trial reportNutrition journal2011

The effects of varying protein and energy intakes on the growth and body composition of very low birth weight infants.

Juan Antonio Costa-Orvay, Josep Figueras-Aloy, Gerardo Romera, Ricardo Closa-Monasterolo, Xavier Carbonell-Estrany

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrition journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 4 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 83 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Higher versus lower protein intake in formula-fed low birth weight infants.The Cochrane database of systematic reviews · 2020
    Pooled it
  4. Higher versus lower protein intake in formula-fed low birth weight infants.The Cochrane database of systematic reviews · 2014
    Pooled it
  5. Trial
  6. Article
  7. Article
  8. Associations of human milk lactoferrin with measures of physical growth in very preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Infant body composition: A comprehensive overview of assessment techniques, nutrition factors, and health outcomes.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2023
    Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Juan Antonio Costa-OrvayNeonatal Unit, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain.
Josep Figueras-Aloy
Gerardo Romera
Ricardo Closa-Monasterolo
Xavier Carbonell-Estrany
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESHospital Clínic de Barcelona · ESInstitut d'Investigació Sanitària Pere Virgili · ESUniversitat de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the effects of high dietary protein and energy intake on the growth and body composition of very low birth weight (VLBW) infants. STUDY

designThirty-eight VLBW infants whose weights were appropriate for their gestational ages were assessed for when they could tolerate oral intake for all their nutritional needs. Thirty-two infants were included in a longitudinal, randomized clinical trial over an approximate 28-day period. One control diet (standard preterm formula, group A, n = 8, 3.7 g/kg/d of protein and 129 kcal/kg/d) and two high-energy and high-protein diets (group B, n = 12, 4.2 g/kg/d and 150 kcal/kg/d; group C, n = 12, 4.7 g/kg/d and 150 kcal/kg/d) were compared. Differences among groups in anthropometry and body composition (measured with bioelectrical impedance analysis) were determined. An enriched breast milk group (n = 6) served as a descriptive reference group.

resultsGroups B and C displayed greater weight gains and higher increases in fat-free mass than group A.

conclusionAn intake of 150 kcal/kg/d of energy and 4.2 g/kg/d of protein increases fat-free mass accretion in VLBW infants.

Indexed as

Dietary SupplementsEnergy IntakeInfant FormulaBody CompositionDietary CarbohydratesDietary FatsDietary ProteinsFemaleHumansInfantInfant, NewbornInfant, PrematureInfant, Very Low Birth WeightLongitudinal StudiesMaleMilk, HumanDietary CarbohydratesDietary FatsDietary Proteins

Identifiers

PMID22206271
PMCPMC3265432
OpenAlexW2166477251

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.