ArticleAmerican journal of cancer research2012
The warts gene as a novel target of the Drosophila DRE/DREF transcription pathway.
Article in American journal of cancer research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- ZBED1/DREF: A transcription factor that regulates cell proliferation.Oncology letters · 2020Review
- Effect and mechanism of RNAi targeting WWTR1 on biological activity of gastric cancer cells SGC7901.Molecular medicine reports · 2018Article
- Phosphine inhibits transcription of the catalase gene through the DRE/DREF system in Drosophila melanogaster.Scientific reports · 2017Article
- Prediction of non-small cell lung cancer metastasis-associated microRNAs using bioinformatics.American journal of cancer research · 2015Article
- Loss of putzig Activity Results in Apoptosis during Wing Imaginal Development in Drosophila.PloS one · 2015Article
- The Hippo pathway as a target of the Drosophila DRE/DREF transcriptional regulatory pathway.Scientific reports · 2014Article
- Drosophila myeloid leukemia factor acts with DREF to activate the JNK signaling pathway.Oncogenesis · 2014Article
- Nuclear transcription factor Y and its roles in cellular processes related to human disease.American journal of cancer research · 2013Article
- DREF is involved in the steroidogenesis via regulation of shadow gene.American journal of cancer research · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Hippo tumor suppressor pathway in Drosophila represses expression of DIAP1 and Cyclin E via inactivation of the transcription co-activator Yorkie, resulting in cell cycle arrest and induction of apoptosis. The warts (wts) gene is well known as a core kinase in this pathway, but its transcriptional regulation has yet to be clarified. In Drosophila, DREF binds to a target sequence named DRE (5'-TATCGATA) and regulates transcription of cell proliferation-related genes containing the DRE sequence in their promoter regions. Here we found half reduction of the wts gene dose to enhance the DREF-induced rough eye phenotype, suggesting a DREF genetic interaction with the Hippo pathway in vivo. Three DREs indentified in the wts gene promoter region exhibited strong promoter activity with a luciferase transient expression assay in Drosophila S2 cells, this decreasing under DREF-RNAi conditions. In addition, knockdown of DREF in S2 cells reduced the level of endogenous wts mRNA. Chromatin immunoprecipitation assays with anti-DREF antibody revealed that DREF binds specifically to the wts gene promoter region containing DREs in vivo. These results indicate that the DRE/DREF pathway is required for transcriptional regulation of the wts gene, indicating a novel link between the DRE/DREF and the Hippo pathways.
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Identifiers
22206044PMC3236570W132412473What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.