ArticleAmerican journal of cancer research2012
Infrared spectroscopy and microscopy in cancer research and diagnosis.
Article in American journal of cancer research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
89 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Imaging and quantifying drug delivery in skin - Part 2: Fluorescence andvibrational spectroscopic imaging methods.Advanced drug delivery reviews · 2020Pooled it
- Zwitterionic Ionogels Resolving the Trade-Off Between Mechanical Strength and Autonomous Self-Healing for Iontronics.Nano-micro letters · 2026Article
- A Universal Approach to Mie Scatter Correction in FTIR Analysis of Microsized Samples.ACS omega · 2025Article
- Exploring Fourier-Transform Infrared Microscopy for Scabies Mite Detection in Human Tissue Sections: A Preliminary Technical Feasibility Study.International journal of molecular sciences · 2025Article
- Bidirectional quantitative scattering microscopy.Nature communications · 2025Article
- Infrared spectral analysis of gastrointestinal neuroendocrine tumors reveals diagnostic biomarkers.Scientific reports · 2025Article
- FTIR-based machine learning for prediction of malignant transformation in oral epithelial dysplasia.The Analyst · 2025Article
- Chemical imaging for biological systems: techniques, AI-driven processing, and applications.Journal of materials chemistry. B · 2025Review
- Unlocking the Potential of Machine Learning in Enhancing Quantum Chemical Calculations for Infrared Spectral Prediction.ACS omega · 2025Article
- Review
- Advancements in Cancer Care by Exploring Multimodality Imaging Techniques and their Applications.Current medical imaging · 2025Review
- Early Mortality Prediction in Intensive Care Unit Patients Based on Serum Metabolomic Fingerprint.International journal of molecular sciences · 2024Article
- Synchrotron nano-FTIR spectroscopy for probing anticancer drugs at subcellular scale.Scientific reports · 2024Article
- Plasma infrared fingerprinting with machine learning enables single-measurement multi-phenotype health screening.Cell reports. Medicine · 2024Article
- Single-frame transmission and phase imaging using off-axis holography with undetected photons.Scientific reports · 2024Article
- A Study of the Association between Primary Oral Pathologies (Dental Caries and Periodontal Diseases) Using Synchrotron Molecular FTIR Spectroscopy in View of the Patient's Personalized Clinical Picture (Demographics and Anamnesis).International journal of molecular sciences · 2024Article
- Saliva Based Diagnostic Prediction of Oral Squamous Cell Carcinoma using FTIR Spectroscopy.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Advancements in medical research: Exploring Fourier Transform Infrared (FTIR) spectroscopy for tissue, cell, and hair sample analysis.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Review
- Discovery of Delirium Biomarkers through Minimally Invasive Serum Molecular Fingerprinting.Metabolites · 2024Article
- Long-term, non-invasive FTIR detection of low-dose ionizing radiation exposure.Scientific reports · 2024Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the middle of 20(th) century infrared (IR) spectroscopy coupled to microscopy (IR microspectroscopy) has been recognized as a non destructive, label free, highly sensitive and specific analytical method with many potential useful applications in different fields of biomedical research and in particular cancer research and diagnosis. Although many technological improvements have been made to facilitate biomedical applications of this powerful analytical technique, it has not yet properly come into the scientific background of many potential end users. Therefore, to achieve those fundamental objectives an interdisciplinary approach is needed with basic scientists, spectroscopists, biologists and clinicians who must effectively communicate and understand each other's requirements and challenges. In this review we aim at illustrating some principles of Fourier transform (FT) Infrared (IR) vibrational spectroscopy and microscopy (microFT-IR) as a useful method to interrogate molecules in specimen by mid-IR radiation. Penetrating into basics of molecular vibrations might help us to understand whether, when and how complementary information obtained by microFT-IR could become useful in our research and/or diagnostic activities. MicroFT-IR techniques allowing to acquire information about the molecular composition and structure of a sample within a micrometric scale in a matter of seconds will be illustrated as well as some limitations will be discussed. How biochemical, structural, and dynamical information about the systems can be obtained by bench top microFT-IR instrumentation will be also presented together with some methods to treat and interpret IR spectral data and applicative examples. The mid-IR absorbance spectrum is one of the most information-rich and concise way to represent the whole "… omics" of a cell and, as such, fits all the characteristics for the development of a clinically useful biomarker.
Indexed as
Identifiers
22206042PMC3236568What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.