ArticlePLoS neglected tropical diseases2011
Multifaceted population structure and reproductive strategy in Leishmania donovani complex in one Sudanese village.
Article in PLoS neglected tropical diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The Relevance of the Predominant Clonal Evolution (PCE) Model for the Molecular Epidemiology and Subspecific Taxonomy ofPathogens (Basel, Switzerland) · 2025Review
- Article
- Altitude and hillside orientation shapes the population structure of the Leishmania infantum vector Phlebotomus ariasi.Scientific reports · 2020Article
- Analysis of genetic polymorphisms and tropism in East African Leishmania donovani by Amplified Fragment Length Polymorphism and kDNA minicircle sequencing.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2018Article
- Variability of Cutaneous Leishmaniasis Lesions Is Not Associated with Genetic Diversity ofThe American journal of tropical medicine and hygiene · 2017Article
- Genetic Diversity and Population Structure of Leishmania infantum from Southeastern France: Evaluation Using Multi-Locus Microsatellite Typing.PLoS neglected tropical diseases · 2016Article
- Species typing in dermal leishmaniasis.Clinical microbiology reviews · 2015Review
- Multilocus microsatellite typing of Leishmania and clinical applications: a review.Parasite (Paris, France) · 2015Review
- Leishmania donovani populations in Eastern Sudan: temporal structuring and a link between human and canine transmission.Parasites & vectors · 2014Article
- Genetic structure and evolution of the Leishmania genus in Africa and Eurasia: what does MLSA tell us.PLoS neglected tropical diseases · 2013Article
- Reproductive clonality of pathogens: a perspective on pathogenic viruses, bacteria, fungi, and parasitic protozoa.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
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9 authors.
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Abstract
Leishmania species of the subgenus Leishmania and especially L. donovani are responsible for a large proportion of visceral leishmaniasis cases. The debate on the mode of reproduction and population structure of Leishmania parasites remains opened. It has been suggested that Leishmania parasites could alternate different modes of reproduction, more particularly clonality and frequent recombinations either between related individuals (endogamy) or between unrelated individuals (outcrossing) within strongly isolated subpopulations. To determine whether this assumption is generalized to other species, a population genetics analysis within Leishmania donovani complex strains was conducted within a single village. The results suggest that a mixed-mating reproduction system exists, an important heterogeneity of subsamples and the coexistence of several genetic entities in Sudanese L. donovani. Indeed, results showed significant genetic differentiation between the three taxa (L. donovani, L. infantum and L. archibaldi) and between the human or canine strains of such taxa, suggesting that there may be different imbricated transmission cycles involving either dogs or humans. Results also are in agreement with an almost strict specificity of L. donovani stricto sensu to human hosts. This empirical study demonstrates the complexity of population structure in the genus Leishmania and the need to pursue such kind of analyses at the smallest possible spatio-temporal and ecological scales.
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