ArticlePLoS neglected tropical diseases2011
Tropheryma whipplei: a common bacterium in rural Senegal.
Article in PLoS neglected tropical diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 67 citations in OpenAlex.
- Whipple's disease with multiple serous effusions as the clinical manifestation: a case report and literature review.Infectious diseases of poverty · 2026Review
- Retraction: Tropheryma whipplei: A common bacterium in rural Senegal.PLoS neglected tropical diseases · 2025Article
- Molecular detection of Tropheryma whipplei DNA: a crucial tool for diagnosing Whipple's disease in the brain. Illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Article
- Prevalence estimation of Tropheryma whipplei in duodenal biopsy tissues of Koreans.Annals of clinical microbiology and antimicrobials · 2024Article
- Prevalence and detection of Tropheryma whipplei in the stools of Korean patients with diarrhea using real-time PCRs.Annals of clinical microbiology and antimicrobials · 2022Article
- Expression of Concern: Tropheryma whipplei: A Common Bacterium in Rural Senegal.PLoS neglected tropical diseases · 2022Article
- Article
- Tropheryma whipplei in the stool samples of children with acute diarrhea: a study from Tehran, Iran.BMC infectious diseases · 2022Article
- Recurrent thrombosis as a clinical presentation of Whipple disease.BMJ case reports · 2022Article
- Seasonal Patterns of Enteric Pathogens in Colombian Indigenous People-A More Pronounced Effect on Bacteria Than on Parasites.Pathogens (Basel, Switzerland) · 2022Article
- Intestinal Colonization withMicroorganisms · 2021Article
- Potential Role for Urine Polymerase Chain Reaction in the Diagnosis of Whipple's Disease.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Tropheryma whipplei Infection (Whipple Disease) in the USA.Digestive diseases and sciences · 2019Article
- Clinical Manifestations, Treatment, and Diagnosis of Tropheryma whipplei Infections.Clinical microbiology reviews · 2017Review
- Implementation of Syndromic Surveillance Systems in Two Rural Villages in Senegal.PLoS neglected tropical diseases · 2016Article
- Tropheryma whipplei as a Cause of Epidemic Fever, Senegal, 2010-2012.Emerging infectious diseases · 2016Article
- From past sailors' eras to the present day: scurvy as a surprising manifestation of an uncommon gastrointestinal disease.BMJ case reports · 2015Article
- The detection of vector-borne-disease-related DNA in human stool paves the way to large epidemiological studies.European journal of epidemiology · 2015Article
- Molecular Detection of Fastidious and Common Bacteria as Well as Plasmodium spp. in Febrile and Afebrile Children in Franceville, Gabon.The American journal of tropical medicine and hygiene · 2015Article
Corrections and comments
- Retraction · 2025-06-26Concerns/Issues about Human Subject Welfare · Conflict of Interest · Investigation by Journal/Publisher · Lack of IRB/IACUC Approval and/or Compliance · Objections by Author(s) · Objections by Company/Institution · Upgrade/Update of Prior Notice(s) ·
- Expression of concern · 2022-12-13Investigation by Journal/Publisher · Updated to Retraction ·
- Expression of concern
- Retracted
Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTropheryma whipplei is known as the cause of Whipple's disease, but it is also an emerging pathogen, detected in stool, that causes various chronic localized infections without histological digestive involvement and is associated with acute infections, including gastroenteritis and bacteremia. METHODS/PRINCIPAL
findingsWe conducted a study in 2008 and 2009 using 497 non-diarrheic and diarrheic stool samples, 370 saliva samples, 454 sera samples and 105 samples obtained from water samples in two rural Sine-Saloum villages (Dielmo and Ndiop) in Senegal. The presence of T. whipplei was investigated by using specific quantitative PCR. Genotyping was performed on positive samples. A serological analysis by western blotting was performed to determine the seroprevalence and to detect seroconversion. Overall, T. whipplei was identified in 31.2% of the stool samples (139/446) and 3.5% of the saliva samples (13/370) obtained from healthy subjects. The carriage in the stool specimens was significantly (p<10(-3)) higher in children who were between 0 and 4 years old (60/80, 75%) compared to samples obtained from individuals who were between 5 to 10 years old (36/119, 30.2%) or between 11 and 99 years old (43/247, 17.4%). The carriage in the stool was also significantly more common (p = 0.015) in subjects with diarrhea (25/51, 49%). We identified 22 genotypes, 16 of which were new. Only one genotype (#53) was common to both villages. Among the specific genotypes, one (#52) was epidemic in Dielmo (15/28, 53.4%, p<10(-3)) and another (#49) in Ndiop (27.6%, p = 0.002). The overall seroprevalence was estimated at 72.8% (291/400). Seroconversion was detected in 66.7% (18/27) of children for whom PCR became positive in stools between 2008 and 2009. CONCLUSIONS/SIGNIFICANCE: T. whipplei is a common bacterium in the Sine-Saloum area of rural Senegal that is contracted early in childhood. Epidemic genotypes suggest a human transmission of the bacterium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.