ArticlePloS one2011
The DNA repair gene APE1 T1349G polymorphism and risk of gastric cancer in a Chinese population.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Association of APE1 Gene Asp148Glu Variant with Digestive Cancer: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2015Pooled it
- Relationship between apurinic endonuclease 1 Asp148Glu polymorphism and gastrointestinal cancer risk: An updated meta-analysis.World journal of gastroenterology · 2015Pooled it
- Pooled it
- Pooled it
- Genetic contribution betweenSaudi journal of biological sciences · 2023Article
- Review
- NIPS, a 3D network-integrated predictor of deleterious protein SAPs, and its application in cancer prognosis.Scientific reports · 2018Article
- Common polymorphisms of theBioscience reports · 2017Article
- The Investigation of Polymorphisms in DNA Repair Genes (XRCC1, APE1 and XPD) in Women with Polycystic Ovary SyndromeAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Prediction of Lymph Node Metastases in Gastric Cancer by Serum APE1 Expression.Journal of Cancer · 2017Article
- AT101 exerts a synergetic efficacy in gastric cancer patients with 5-FU based treatment through promoting apoptosis and autophagy.Oncotarget · 2016Article
- Impact of reduced levels of APE1 transcripts on the survival of patients with urothelial carcinoma of the bladder.Oncology reports · 2015Article
- The association of ApE1 -656T>G and 1349T>G polymorphisms and idiopathic male infertility risk.International urology and nephrology · 2015Article
- Association between polymorphisms in APE1 and XRCC1 and the risk of gastric cancer in Korean population.International journal of clinical and experimental medicine · 2015Article
- Upregulation of PD-L1 and APE1 is associated with tumorigenesis and poor prognosis of gastric cancer.Drug design, development and therapy · 2015Article
- Genetic Variation in the 3'-Untranslated Region of NBN Gene Is Associated with Gastric Cancer Risk in a Chinese Population.PloS one · 2015Article
- High γ-radiation sensitivity is associated with increased gastric cancer risk in a Chinese Han population: a case-control analysis.PloS one · 2012Article
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5 authors.
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Abstract
backgroundApurinic/apyrimidinic endonuclease 1 (APE1) has a central role in the repair of apurinic apyrimidic sites through both its endonuclease and its phosphodiesterase activities. A common APE1 polymorphism, T1349G (rs3136820), was previously shown to be associated with the risk of cancers.
objectiveWe hypothesized that the APE1 T1349G polymorphism is also associated with risk of gastric cancer.
methodsIn a hospital-based case-control study of 338 case patients with newly diagnosed gastric cancer and 362 cancer-free controls frequency-matched by age and sex, we genotyped the T1349G polymorphism and assessed its associations with risk of gastric cancer.
resultsCompared with the APE1 TT genotype, individuals with the variant TG/GG genotypes had a significantly increased risk of gastric cancer (odds ratio = 1.69, 95% confidence interval = 1.19-2.40), which was more pronounced among subgroups of aged ≤ 60 years, male, ever smokers, and ever drinkers. Further analyses revealed that the variant genotypes were associated with an increased risk for diffuse-type, low depth of tumor infiltration (T1 and T2), and lymph node metastasis gastric cancer.
conclusionsThe APE1 T1349G polymorphism may be a marker for the development of gastric cancer in the Chinese population. Larger studies are required to validate these findings in diverse populations.
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