Evidence map›Paper›PMID 22205791›Full record

ArticleJournal of clinical microbiology2012

Individual Plasmodium vivax msp1 variants within polyclonal P. vivax infections display different propensities for relapse.

Jessica T Lin, Jonathan J Juliano, Oksana Kharabora, Rithy Sem, Feng-Chang Lin, Sinuon Muth, Didier Ménard, Chansuda Wongsrichanalai, William O Rogers, Steven R Meshnick

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Jessica T LinDivision of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA. jessica_lin@med.unc.edu
Jonathan J Juliano
Oksana Kharabora
Rithy Sem
Feng-Chang Lin
Sinuon Muth
Didier Ménard
Chansuda Wongsrichanalai
William O Rogers
Steven R Meshnick
University of North Carolina at Chapel Hill · USCambodia National Malaria Center · KHCambodia-Oxford Medical Research Unit · KHInstitut Pasteur du Cambodge · KH

Funding

INFECTIOUS DISEASE PATHOGENESIS TRAININGT32AI007151 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JULIANO, JONATHAN J · 1985 to 2024
$5.5M
Within Host Selection of P. falciparum Variants by Artemisinin Combination TherapR01AI089819 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JULIANO, JONATHAN J · 2010 to 2014
$1.9M
Prevalence and fitness of drug resistant minority variant mutations in PlasmodiumR21AI076785 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MESHNICK, STEVEN RICHARD · 2008 to 2009
$404k
NIAID NIH HHS 5T32AI0715132NIAID NIH HHS AI076785NIAID NIH HHS AI089819NIAID NIH HHS R01 AI089819NIAID NIH HHS R21 AI076785NIAID NIH HHS T32 AI007151
6 · The paper itself

Abstract

Using a newly developed Plasmodium vivax merozoite surface protein 1 gene (Pvmsp1) heteroduplex tracking assay, we genotyped 107 P. vivax infections in individuals from Cambodia, 45 of whom developed recurrent parasitemia within 42 days. The majority of isolates were polyclonal, but recurrent parasitemias displayed fewer variants compared to initial parasitemias. Two Pvmsp1 gene variants occurred more frequently in the initial genotypes of those who developed recurrent parasitemia, representing the first time P. vivax variants associated with a higher risk of relapse have been described.

Indexed as

Genetic VariationGenotypeGenotyping TechniquesHumansMalaria, VivaxMerozoite Surface Protein 1Molecular TypingPlasmodium vivaxRecurrenceSensitivity and SpecificityYoung AdultMerozoite Surface Protein 1

Identifiers

PMID22205791
PMCPMC3318509
OpenAlexW2030850444

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.