ArticleThe Journal of clinical endocrinology and metabolism2012
Latent autoimmune diabetes of adults is phenotypically similar to type 1 diabetes in a minority population.
Article in The Journal of clinical endocrinology and metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Ensemble machine learning reveals key features for diabetes duration from electronic health records.PeerJ. Computer science · 2024Article
- Incidence and associates of diabetic ketoacidosis in a community-based cohort: the Fremantle Diabetes Study Phase II.BMJ open diabetes research & care · 2020Observational
- Structural Properties of Gene Promoters Highlight More than Two Phenotypes of Diabetes.PloS one · 2015Article
- Loss of sex difference in high-density lipoprotein cholesterol in diabetic women during acute stress.The Journal of clinical endocrinology and metabolism · 2014Article
- LADA: time for a new definition.Diabetes · 2013Article
- A COMMENTARY ON CLASSIFICATION OF DIABETES: LATENT AUTOIMMUNE DIABETES IN ADULTS (LADA) OR INTERMEDIARY DIABETES MELLITUS (IDM)?Acta endocrinologica (Bucharest, Romania : 2005)Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
contextLatent autoimmune diabetes of adults (LADA) is a form of autoimmune diabetes that has been classified as part of type 1 diabetes or as a distinct clinical entity. Its precise place as a disease category is therefore controversial.
objectiveThe objective of this study was to further examine this issue by comparing the phenotypes of LADA and type 1 diabetes in a predominately minority population. PATIENTS AND
methodsWe studied 126 subjects who were anti-glutamic acid decarboxylase antibody-positive in two separate studies--63 subjects in an outpatient study (study 1), and 63 inpatients after resolution of ketoacidosis (study 2). Clinical and biochemical phenotyping was performed in all patients in each group.
resultsFew significant differences were found in the clinical or biochemical phenotypes in patients classified as LADA when compared with type 1 diabetes. Adiposity, body mass index, waist/hip ratio, fasting plasma C-peptide, serum high-density lipoprotein cholesterol, and triglycerides were all similar. The only distinguishing feature was a history of hypertension (study 1) or systolic blood pressure (study 2). Also, a history of ketoacidosis did not influence the phenotype of LADA in the outpatients in any discernable way.
conclusionsWe conclude that LADA and type 1 diabetes are phenotypically indistinguishable in this predominantly minority population with a mean duration of glutamic acid decarboxylase antibody-positive diabetes of about 8 yr.
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