ArticleThe Journal of biological chemistry2012
Retagging identifies dendritic cell-specific intercellular adhesion molecule-3 (ICAM3)-grabbing non-integrin (DC-SIGN) protein as a novel receptor for a major allergen from house dust mite.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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Who cites it
32 citing papers in PubMed, 56 citations in OpenAlex.
- The very low density lipoprotein receptor attenuates house dust mite-induced airway inflammation by suppressing dendritic cell-mediated adaptive immune responses.Journal of immunology (Baltimore, Md. : 1950) · 2014Trial
- The potential immunomodulatory role of human milk oligosaccharides in prevention of viral infections and development of asthma in early life.Frontiers in immunology · 2025Review
- Monosaccharide coating modulate the intracellular trafficking of gold nanoparticles in dendritic cells.Materials today. Bio · 2024Article
- LMAN1 is a receptor for house dust mite allergens.Cell reports · 2023Article
- C-Type Lectin Receptor Mediated Modulation of T2 Immune Responses to Allergens.Current allergy and asthma reports · 2023Review
- Review
- Differential uptake of three clinically relevant allergens by human plasmacytoid dendritic cells.Clinical and molecular allergy : CMA · 2021Article
- A positive feedback loop reinforces the allergic immune response in human peanut allergy.The Journal of experimental medicine · 2021Article
- Effect of O-linked glycosylation on the antigenicity, cellular uptake and trafficking in dendritic cells of recombinant Ber e 1.PloS one · 2021Article
- Inhalant Mammal-Derived Lipocalin Allergens and the Innate Immunity.Frontiers in allergy · 2021Review
- Characterization of Innate Immune Responses to House Dust Mite Allergens: Pitfalls and Limitations.Frontiers in allergy · 2021Review
- Insights Into Mucosal Innate Immune Responses in House Dust Mite-Mediated Allergic Asthma.Frontiers in immunology · 2020Review
- Role of T lymphocytes and papain enzymatic activity in the protection induced by the cysteine protease againstJournal of advanced research · 2019Article
- C-Type Lectin Receptors in Asthma.Frontiers in immunology · 2018Review
- N-glycan in cockroach allergen regulates human basophil function.Immunity, inflammation and disease · 2017Article
- T Cells in Allergic Asthma: Key Players Beyond the Th2 Pathway.Current allergy and asthma reports · 2017Review
- The role of indoleamine 2,3-dioxygenase-aryl hydrocarbon receptor pathway in the TLR4-induced tolerogenic phenotype in human DCs.Scientific reports · 2017Article
- Patterns of IgE responses to multiple allergen components and clinical symptoms at age 11 years.The Journal of allergy and clinical immunology · 2015Article
- Article
- Glycoproteomic analysis of seven major allergenic proteins reveals novel post-translational modifications.Molecular & cellular proteomics : MCP · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Dendritic cells (DCs) have been shown to play a key role in the initiation and maintenance of immune responses to microbial pathogens as well as to allergens, but the exact mechanisms of their involvement in allergic responses and Th2 cell differentiation have remained elusive. Using retagging, we identified DC-SIGN as a novel receptor involved in the initial recognition and uptake of the major house dust mite and dog allergens Der p 1 and Can f 1, respectively. To confirm this, we used gene silencing to specifically inhibit DC-SIGN expression by DCs followed by allergen uptake studies. Binding and uptake of Der p 1 and Can f 1 allergens was assessed by ELISA and flow cytometry. Intriguingly, our data showed that silencing DC-SIGN on DCs promotes a Th2 phenotype in DC/T cell co-cultures. These findings should lead to better understanding of the molecular basis of allergen-induced Th2 cell polarization and in doing so paves the way for the rational design of novel intervention strategies by targeting allergen receptors on innate immune cells or their carbohydrate counterstructures on allergens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.