ArticleJournal of neurophysiology2012
Anion size modulates salt taste in rats.
Article in Journal of neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- Neural Processing of Taste-Related Signals in the Mediodorsal Thalamus of Mice.bioRxiv : the preprint server for biology · 2025Article
- Sodium Intake and Disease: Another Relationship to Consider.Nutrients · 2023Review
- Analysis of the rat chorda tympani nerve response to "super salty" sodium carbonate.Chemical senses · 2023Article
- A molecular perspective on identifying TRPV1 thermosensitive regions and disentangling polymodal activation.Temperature (Austin, Tex.) · 2023Review
- The impact of excessive salt intake on human health.Nature reviews. Nephrology · 2022Review
- Functional expression of TMEM16A in taste bud cells.The Journal of physiology · 2021Article
- Optogenetic Stimulation of Type I GAD65The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The Role of the Anion in Salt (NaCl) Detection by Mouse Taste Buds.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Spilanthol Enhances Sensitivity to Sodium in Mouse Taste Bud Cells.Chemical senses · 2019Article
- Selective Effects of Temperature on the Sensory Irritation but not Taste of NaCl and Citric Acid.Chemical senses · 2019Article
- Thirst Increases Chorda Tympani Responses to Sodium Chloride.Chemical senses · 2017Article
- Sodium Carbonate is Saltier Than Sodium Chloride to Sodium-Depleted Rats.Chemical senses · 2017Article
- Maintenance of Mouse Gustatory Terminal Field Organization Is Disrupted following Selective Removal of Peripheral Sodium Salt Taste Activity at Adulthood.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- The Perceptual Characteristics of Sodium Chloride to Sodium-Depleted Rats.Chemical senses · 2017Article
- Temperature Influences Chorda Tympani Nerve Responses to Sweet, Salty, Sour, Umami, and Bitter Stimuli in Mice.Chemical senses · 2016Article
- Amiloride-Insensitive Salt Taste Is Mediated by Two Populations of Type III Taste Cells with Distinct Transduction Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Molecular mechanisms of taste recognition: considerations about the role of saliva.International journal of molecular sciences · 2015Review
- Peripheral coding of taste.Neuron · 2014Review
- Genetics of taste receptors.Current pharmaceutical design · 2014Review
- TRPM5-dependent amiloride- and benzamil-insensitive NaCl chorda tympani taste nerve response.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The purpose of this study was to investigate the influence of anion size and the contribution of the epithelial sodium channel (ENaC) and the transient receptor potential vanilloid-1 (TRPV1) channel on sodium-taste responses in rat chorda tympani (CT) neurons. We recorded multiunit responses from the severed CT nerve and single-cell responses from intact, narrowly tuned and broadly tuned, salt-sensitive neurons in the geniculate ganglion simultaneously with stimulus-evoked summated potentials to signal when the stimulus contacted the lingual epithelium. Artificial saliva served as the rinse and solvent for all stimuli (0.3 M NH(4)Cl, 0.5 M sucrose, 0.03-0.5 M NaCl, 0.01 M citric acid, 0.02 M quinine hydrochloride, 0.1 M KCl, and 0.03-0.5 M Na-gluconate). We used the pharmacological antagonist benzamil to assess NaCl responses mediated by ENaC, and SB-366791 and cetylpyridinium chloride to assess responses mediated by TRPV1. CT nerve responses were greater to NaCl than Na-gluconate at each concentration; this was attributed mostly to broadly tuned, acid-generalist neurons that responded with higher frequency and shorter latency to NaCl than Na-gluconate. In contrast, narrowly tuned NaCl-specialist neurons responded more similarly to the two salts, but with subtle differences in temporal pattern. Benzamil reduced CT nerve and single-cell responses only of narrowly tuned neurons to NaCl. Surprisingly, SB-366791 and cetylpyridinium chloride were without effect on CT nerve or single-cell NaCl responses. Collectively, our data demonstrate the critical role that apical ENaCs in fungiform papillae play in processing information about sodium by peripheral gustatory neurons; the role of TRPV1 channels is an enigma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.