Evidence map›Paper›PMID 22205604›Full record

Trial reportInvestigative ophthalmology & visual science2012

A randomized trial using progressive addition lenses to evaluate theories of myopia progression in children with a high lag of accommodation.

David A Berntsen, Loraine T Sinnott, Donald O Mutti, Karla Zadnik

2 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Investigative ophthalmology & visual science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 75 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 9 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00335049 nacompletednot on this map

Study of Theories About Myopia Progression (STAMP)

TypeinterventionalSponsorOhio State UniversityRan2006 to 2010Enrolled85ConditionsMyopiaArmsprogressive addition spectacle lens (bifocal), Single Vision Lenses (SVLs)
NCT02955927 nacompletednot on this mapstarted 2016, after this paper: background citation

Combined Atropine With Orthokeratology in Childhood Myopia Control (AOK) -A Randomized Controlled Trial

TypeinterventionalSponsorThe Hong Kong Polytechnic UniversityRan2016 to 2021Enrolled89ConditionsMyopiaArms0.01% atropine eye drops, ortho-k
3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 9 syntheses or guidelines pooled it, 169 citations in OpenAlex.

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  8. Interventions to slow progression of myopia in children.The Cochrane database of systematic reviews · 2020
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  15. MiSight Assessment Study Spain (MASS). A 2-year randomized clinical trial.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018
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  16. A Randomized Trial of Soft Multifocal Contact Lenses for Myopia Control: Baseline Data and Methods.Optometry and vision science : official publication of the American Academy of Optometry · 2017
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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

David A BerntsenUniversity of Houston, College of Optometry, Houston, Texas 77204-2020, USA. dberntsen@optometry.uh.edu
Loraine T Sinnott
Donald O Mutti
Karla Zadnik
SUNY College of Optometry · USThe Ohio State University · USUniversity of Houston · US

Funding

Clinical Vision Scientist Training ProgramK12EY015447 · NEI · OHIO STATE UNIVERSITY · PI ZADNIK, KARLA · 2004 to 2011
$1.7M
NEI NIH HHS K12 EY015447NEI NIH HHS K12-EY015447
6 · The paper itself

Abstract

purposeTo compare the effect of wearing, then ceasing to wear, progressive addition lenses (PALs) versus single vision lenses (SVLs) on myopia progression in children with high accommodative lag to evaluate accommodative lag and mechanical tension as theories of myopia progression.

methodsEighty-five children (age range, 6-11 years) with spherical equivalent (SE) cycloplegic autorefraction between -0.75 D and -4.50 D were randomly assigned to wear SVLs or PALs for 1 year; all children wore SVLs a second year. Children had high accommodative lag and also had near esophoria if their myopia was greater than -2.25 D SE. The primary outcome after each year was the previous year's change in SE.

resultsWhen the children were randomly assigned to SVLs or PALs, the adjusted 1-year changes in SE were -0.52 D (SVL group) and -0.35 D (PAL group; treatment effect = 0.18 D; P = 0.01). When all children wore SVLs the second year, there was no difference in myopia progression between SVL and former PAL wearers (0.06 D; P = 0.50). Accommodative lag was not associated with myopia progression.

conclusionsThe statistically significant, but clinically small, PAL effect suggests that treatments aimed at reducing foveal defocus may not be as effective as previously thought in myopic children with high accommodative lag. Finding no evidence of treatment loss after discontinuing PAL wear supports hyperopic defocus-based theories such as accommodative lag; however, not finding an association between accommodative lag and myopia progression is inconsistent with the PAL effect being due to decreased foveal blur during near work. (Clinical Trials.gov number, NCT00335049.).

Indexed as

EyeglassesAccommodation, OcularChildDisease ProgressionEsotropiaFemaleHumansMaleMyopiaPatient ComplianceRefraction, OcularTreatment Outcome

Identifiers

PMID22205604
PMCPMC3317412
OpenAlexW2051483562

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.