ArticleInvestigative ophthalmology & visual science2012
Natural history of age-related retinal lesions that precede AMD in mice fed high or low glycemic index diets.
Article in Investigative ophthalmology & visual science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Metabolic Effects of High Glycaemic Index Diets: A Systematic Review and Meta-Analysis of Feeding Studies in Mice and Rats.Nutrients · 2017Pooled it
- The gut-eye axis in age-related macular degeneration: from microbial dysbiosis to targeted intervention strategies.Experimental biology and medicine (Maywood, N.J.) · 2026Review
- Predictable Modulation of a Spontaneous Post-translational Modification in Living Cells.Angewandte Chemie (International ed. in English) · 2025Article
- Extracellular Matrix (ECM) Aging in the Retina: The Role of Matrix Metalloproteinases (MMPs) in Bruch's Membrane Pathology and Age-Related Macular Degeneration (AMD).Biomolecules · 2025Review
- The chemical language of protein glycation.Nature chemical biology · 2025Review
- Review
- Glycative stress as a cause of macular degeneration.Progress in retinal and eye research · 2024Review
- Redox Regulation in Age-Related Cataracts: Roles for Glutathione, Vitamin C, and the NRF2 Signaling Pathway.Nutrients · 2023Review
- The Glyoxalase System in Age-Related Diseases: Nutritional Intervention as Anti-Ageing Strategy.Cells · 2021Review
- Autophagic receptor p62 protects against glycation-derived toxicity and enhances viability.Aging cell · 2020Article
- Dietary Patterns, Carbohydrates, and Age-Related Eye Diseases.Nutrients · 2020Review
- A low glycemic diet protects disease-prone Nrf2-deficient mice against age-related macular degeneration.Free radical biology & medicine · 2020Article
- The microbiome and ophthalmic disease.Experimental biology and medicine (Maywood, N.J.) · 2019Review
- Too sweet: Problems of protein glycation in the eye.Experimental eye research · 2019Review
- Mechanistic targeting of advanced glycation end-products in age-related diseases.Biochimica et biophysica acta. Molecular basis of disease · 2018Review
- Adipocytes and intestinal epithelium dysfunctions linking obesity to inflammation induced by high glycemic index pellet-diet inBioscience reports · 2018Article
- Gut microbiota modify risk for dietary glycemia-induced age-related macular degeneration.Gut microbes · 2018Article
- Involvement of a gut-retina axis in protection against dietary glycemia-induced age-related macular degeneration.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Visualization of Dietary Patterns and Their Associations With Age-Related Macular Degeneration.Investigative ophthalmology & visual science · 2017Article
- Dietary glycemic index modulates the behavioral and biochemical abnormalities associated with autism spectrum disorder.Molecular psychiatry · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
purposeEpidemiologic data indicate that people who consume low glycemic index (GI) diets are at reduced risk for the onset and progression of age-related macular degeneration (AMD). The authors sought corroboration of this observation in an animal model.
methodsFive- and 16-month-old C57BL/6 mice were fed high or low GI diets until they were 17 and 23.5 months of age, respectively. Retinal lesions were evaluated by transmission electron microscopy, and advanced glycation end products (AGEs) were evaluated by immunohistochemistry.
resultsRetinal lesions including basal laminar deposits, loss of basal infoldings, and vacuoles in the retinal pigment epithelium were more prevalent in the 23.5- than in the 17-month-old mice. Within each age group, consumption of a high GI diet increased the risk for lesions and the risk for photoreceptor abnormalities and accumulation of AGEs.
conclusionsConsuming high GI diets accelerates the appearance of age-related retinal lesions that precede AMD in mice, perhaps by increasing the deposition of toxic AGEs in the retina. The data support the hypothesis that consuming lower GI diets, or simulation of their effects with nutraceuticals or drugs, may protect against AMD. The high GI-fed C57BL/6 mouse is a new model of age-related retinal lesions that precede AMD and mimic the early stages of disease and may be useful for drug discovery.
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